Novel potent antagonists of human neuropeptide YY5 receptor. Part 1: 2-oxobenzothiazolin-3-acetic acid derivatives

被引：13
|
作者：
Tabuchi, S
Itani, H
Sakata, Y
Oohashi, H
Satoh, Y
机构：
[1] Fujisawa Pharmaceut Co Ltd, Med Chem Res Labs, Yodogawa Ku, Osaka 5328514, Japan
[2] Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Yodogawa Ku, Osaka 5328514, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(02)00113-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel NPY-Y5 antagonist FR73966 was discovered by screening of our in-house chemical library. The analogues were prepared by application of parallel synthesis techniques. Some of the resulting 2-oxobenzo thiazolin-3-acetic acid derivatives exhibited nanomolar binding affinity for human NPY-Y5 receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1171 / 1175
页数：5
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