Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

被引：16

作者：

Gushiken, Masaki ^{[1
]}

Kagiyama, Ippei ^{[1
]}

Kato, Hikaru ^{[1
]}

Kuwana, Toshiyuki ^{[1
]}

Losung, Fitje ^{[2
]}

Mangindaan, Remy E. P. ^{[2
]}

de Voogd, Nicole J. ^{[3
]}

Tsukamoto, Sachiko ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Manado 95115, Indonesia

[3] Nat Biodivers Ctr, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF NATURAL MEDICINES | 2015年 / 69卷 / 04期

关键词：

Polyketide endoperoxides; Marine sponge; Plakortis bergquistae; Antimicrobial; HALICHONDRIOIDES; PEROXIDES;

D O I：

10.1007/s11418-015-0920-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new polyketide endoperoxides, manadodioxans A-E, were isolated from the marine sponge Plakortis bergquistae. Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 mu g/disk, while its oxo congener, manadodioxan D, was inactive.

引用

页码：595 / 600

页数：6

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