First enantioselective synthesis of the antitumour alkaloid (+)-crispine A and determination of its enantiomeric purity by 1H NMR

被引：82

作者：

Szawkalo, J

Zawadzka, A

Wojtasiewicz, K

Leniewski, A

Drabowicz, J

Czarnocki, Z

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Heteroorgan Chem, PL-90363 Lodz, Poland

[2] Warsaw Univ, Fac Chem, PL-02093 Warsaw, Poland

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 22期

关键词：

D O I：

10.1016/j.tetasy.2005.10.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple enantioselective synthesis of the pyrrolo[2, 1-a]]isoquinoline alkaloid (+)-crispine A, based on the use of an asymmetric transfer hydrogenation as the key step, is described. The enantiomeric excesses of the obtained alkaloid samples were determined from H-1 NMR spectra recorded in the presence of (+)-(R)-t-butylphenylphosphinothioic acid as a chiral solvating agent. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3619 / 3621

页数：3

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