First enantioselective synthesis of the antitumour alkaloid (+)-crispine A and determination of its enantiomeric purity by 1H NMR

被引：82
|
作者：
Szawkalo, J
Zawadzka, A
Wojtasiewicz, K
Leniewski, A
Drabowicz, J
Czarnocki, Z
机构：
[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Heteroorgan Chem, PL-90363 Lodz, Poland
[2] Warsaw Univ, Fac Chem, PL-02093 Warsaw, Poland
来源：
TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 22期
关键词：
D O I：
10.1016/j.tetasy.2005.10.007
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A simple enantioselective synthesis of the pyrrolo[2, 1-a]]isoquinoline alkaloid (+)-crispine A, based on the use of an asymmetric transfer hydrogenation as the key step, is described. The enantiomeric excesses of the obtained alkaloid samples were determined from H-1 NMR spectra recorded in the presence of (+)-(R)-t-butylphenylphosphinothioic acid as a chiral solvating agent. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：3619 / 3621
页数：3
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