Tunable pH and redox-responsive drug release from curcumin conjugated γ-polyglutamic acid nanoparticles in cancer microenvironment

被引:26
|
作者
Pillarisetti, Shameer [1 ]
Maya, S. [1 ]
Sathianarayanan, S. [2 ]
Jayakumar, R. [1 ]
机构
[1] Amrita Univ, Ctr Nanosci & Mol Med, Kochi 682041, Kerala, India
[2] Amrita Univ, Sch Pharm, Kochi 682041, Kerala, India
关键词
Core shell NPs; Stimuli-triggered; Controlled release; Polymeric nanoparticles; Curcumin; Drug delivery; HYDROGEN-PEROXIDE; HYALURONIC-ACID; DISULFIDE BOND; TUMOR-CELLS; DELIVERY; DEGRADATION; DOXORUBICIN; GLUTATHIONE; ACTIVATION; RESISTANCE;
D O I
10.1016/j.colsurfb.2017.08.057
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Tunable pH and redox responsive polymer was prepared using y-polyglutamic acid (gamma-PGA) with linker 3-mercaptopropionic acid (3-MPA) (gamma-PGA_SH) via oxidation to obtain redox responsive disulfide (gamma-PGA_SS) backbone and adipic acid dihydrazide (ADH) (gamma-PGA_SSADH) with hydrazide functional group for pH responsiveness. Further curcumin (Cur) was conjugated through hydrazone bond of the gamma-PGA_SSADH via Schiff base reaction to obtain (gamma-PGA_SSADH_Cur). The prepared systems were characterized by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, Electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Qq-TOF-MS/MS) and Solid state nuclear magnetic resonance (SS NMR) techniques. gamma-PGA_SSADH_Cur formed self-assembled core shell nanoparticles (NPs) in existence of stabilized aqueous medium. gamma-PGA_SSADH_Cur NPs maintained its stability in physiological condition. NPs tunable Cur release and cytotoxicity were observed for gamma-PGA_SSADH_Cur NPs in both acidic and redox conditions mimicking the cancer microenvironment. gamma-PGA_SSADH_Cur NPs uptake study showed via endocytosis mechanism resulted in the lysosomal entrapment of these NPs within the cell. gamma-PGA_SSADH_Cur NPs exhibited a dual stimuli responsive drug delivery and can be used as a smart and potential drug delivery system in cancer microenvironment. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:809 / 819
页数:11
相关论文
共 50 条
  • [31] One-Pot Synthesis of Redox-Responsive Polymers-Coated Mesoporous Silica Nanoparticles and Their Controlled Drug Release
    Sun, Jiao-Tong
    Piao, Ji-Gang
    Wang, Long-Hai
    Javed, Mohsin
    Hong, Chun-Yan
    Pan, Cai-Yuan
    MACROMOLECULAR RAPID COMMUNICATIONS, 2013, 34 (17) : 1387 - 1394
  • [32] One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles
    Kopoleva, Elena
    Lebedev, Maksim D.
    Postovalova, Alisa
    Rogova, Anna
    Fatkhutdinova, Landysh
    Epifanovskaya, Olga
    Goncharenko, Alexander A.
    Kremleva, Arina V.
    Domracheva, Nadezhda
    Bukatin, Anton S.
    Muslimov, Albert R.
    Koroleva, Aleksandra
    Zhizhin, Evgeniy V.
    Lepik, Kirill V.
    Timin, Alexander S.
    Peltek, Oleksii
    Zyuzin, Mikhail V.
    NANO LETTERS, 2023, 23 (23) : 10811 - 10820
  • [33] Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(β-hydroxyl amine) for Drug Delivery
    Li, Dawei
    Bu, Yazhong
    Zhang, Lining
    Wang, Xing
    Yang, Yanyu
    Zhuang, Yaping
    Yang, Fei
    Shen, Hong
    Wu, Decheng
    BIOMACROMOLECULES, 2016, 17 (01) : 291 - 300
  • [34] Porous silica nanoparticles capped with polyethylenimine/green carbon dots for pH/redox responsive drug release
    Zhang, Qianqian
    Li, Xinli
    Peng, Lichao
    Zou, Xueyan
    Zhao, Yanbao
    INORGANIC CHEMISTRY COMMUNICATIONS, 2021, 123
  • [35] Redox responsive xylan-SS-curcumin prodrug nanoparticles for dual drug delivery in cancer therapy
    Sauraj
    Kumar, Vinay
    Kumar, Bijender
    Priyadarshi, Ruchir
    Deeba, Farha
    Kulshreshtha, Anurag
    Kumar, Anuj
    Agrawal, Garima
    Gopinath, P.
    Negi, Yuvraj Singh
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 107
  • [36] Meta-analysis of In Vitro Drug-Release Parameters Reveals Predictable and Robust Kinetics for Redox-Responsive Drug-Conjugated Therapeutic Nanogels
    Morgulchik, Nelli
    Kamaly, Nazila
    ACS APPLIED NANO MATERIALS, 2021, 4 (05) : 4256 - 4268
  • [37] Redox-responsive and pH-sensitive nanoparticles enhanced stability and anticancer ability of erlotinib to treat lung cancer in vivo
    Tan, Sheng
    Wang, Guoxiang
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2017, 11 : 3519 - 3529
  • [38] Redox-responsive hyaluronic acid-based nanoparticles for targeted photodynamic therapy/chemotherapy against breast cancer
    Wang, Rujuan
    Yang, Haotong
    Khan, Abdur Rauf
    Yang, Xiaoye
    Xu, Jiangkang
    Ji, Jianbo
    Zhai, Guangxi
    Journal of Colloid and Interface Science, 2021, 598 : 213 - 228
  • [39] Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release
    Demirel, Gokcen Birlik
    Aygul, Ebru
    Dag, Aydan
    Atasoy, Sezen
    Cimen, Zeynep
    Cetin, Busra
    ACS APPLIED BIO MATERIALS, 2020, 3 (08) : 4949 - 4961
  • [40] Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy
    Zhang, Mengen
    Zhu, Jingyi
    Zheng, Yun
    Guo, Rui
    Wang, Shige
    Mignani, Serge
    Caminade, Anne-Marie
    Majoral, Jean-Pierre
    Shi, Xiangyang
    PHARMACEUTICS, 2018, 10 (03)