Microwave-assisted synthesis of 3'-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

被引：63
|
作者：
Kathrotiya, Harshad G. [1 ]
Patel, Manish P. [1 ]
机构：
[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期
关键词：
4H-Chromene; Indole; DMAP; Microwave irradiation; MCR; In vitro antimicrobial activity; ONE-POT SYNTHESIS; IN-VITRO; ANTIBACTERIAL ACTIVITY; CHROMENE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIOXIDANT; BENZIMIDAZOLES; IRRADIATION; INDOLES; BEARING;
D O I：
10.1007/s00044-011-9861-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study.
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收藏
页码：3406 / 3416
页数：11
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