The LptA protein of Escherichia coli is a periplasmic lipid a-binding protein involved in the lipopolysaccharide export pathway

被引：65

作者：

Tran, An X. ^{[1
]}

Trent, M. Stephen ^{[2
]}

Whitfield, Chris ^{[1
]}

机构：

[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON N1G 2W1, Canada

[2] Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 29期

关键词：

D O I：

10.1074/jbc.M802503200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The LptA protein of Escherichia coli has been implicated in the transport of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Here we provide evidence that LptA binds structurally diverse LPS substrates in vitro and demonstrate that it interacts specifically with the lipid A domain of LPS. These results are consistent with LptA playing a chaperone role in the transport of LPS across the periplasm and have implications for possible assembly models.

引用

页码：20342 / 20349

页数：8

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