Hydrophobicity and the Physico-Chemical Basis of Immunotolerance

被引：15
|
作者：
Kanduc, Darja [1 ]
机构：
[1] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, Via Orabona 4, IT-70125 Bari, Italy
来源：
PATHOBIOLOGY | 2020年 / 87卷 / 04期
关键词：
B-cell receptor; Primary interaction; Pentapeptide frequency; Immunotolerance; Immunogenicity; Hydrophobicity; Van der Waals force; Alum adjuvanticity; Hepatitis C virus-induced cryoglobulinemia; PEPTIDES; EPITOPE; PENTAPEPTIDE; TECHNOLOGIES; DETERMINANT; ANTIBODIES; SELECTION; SEQUENCE; SELF;
D O I：
10.1159/000508903
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This study analyzes the primary electrostatic interaction between the membrane-bound B-cell receptor and antigen peptide determinants, and identifies peptide frequency and hydrophobicity as the main factors that govern and shape immunotolerance versus immunoreactivity.
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页码：268 / 276
页数：9
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