A Novel Method for the Synthesis of Spiro[indoline-Pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]triones by Alum as a Reusable Catalyst

被引：23

作者：

Shirvan, Sadif A. ^{[1
]}

Ghahremanzadeh, Ramin ^{[2
]}

Moghaddam, Mojtaba Mirhosseini ^{[2
]}

Bazgir, Ayoob ^{[3
]}

Zarnani, Amir Hassan ^{[2
,4
]}

Akhondi, Mohammad Mehdi ^{[5
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Omidieh Branch, Omidieh, Iran

[2] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran, Iran

[3] Shahid Beheshti Univ, Dept Chem, GC, Tehran, Iran

[4] Iran Univ Med Sci, Immunol Res Ctr, Tehran, Iran

[5] ACECR, Avicenna Res Inst, Reprod Res Ctr, Tehran, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 04期

关键词：

MAMMALIAN-CELL CYCLE; ONE-POT; 3-COMPONENT SYNTHESIS; 4-COMPONENT SYNTHESIS; ATOM ECONOMY; INHIBITORS; ALKALOIDS; DERIVATIVES;

D O I：

10.1002/jhet.898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of spiro[indoline-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]trione derivatives by a cyclo-condensation reaction of indolin-2-ones, barbituric acids, and 1,3-diphenyl-1H-pyrazol-5-amines with the ionic liquid as an effective green reaction media and in the presence of Alum as a reusable catalyst was reported. Excellent yields of products, green media, use of a reusable catalyst, and short reaction time are the main advantages of this new method.

引用

页码：951 / 954

页数：4

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