Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation

被引：34
|
作者：
Liu, Sensheng [1 ]
Liu, Huan [1 ]
Zhou, Haifeng [1 ,2 ]
Liu, Qixing [1 ]
Lv, Jinliang [2 ]
机构：
[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Res Ctr Green Pharmaceut Technol & Proc, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
[2] Yichang Humanwell Pharmaceut Co Ltd, Yichang 443005, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 04期
基金：
中国国家自然科学基金;
关键词：
HIGHLY ENANTIOSELECTIVE HYDROGENATION; ANTI-MARKOVNIKOV HYDRATION; TERMINAL ALKYNES; REGIOSELECTIVE HYDRATION; AMBIENT-TEMPERATURE; REDUCTIVE HYDRATION; IONIC LIQUID; COMPLEXES; KETONES; WATER;
D O I：
10.1021/acs.orglett.8b00034
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel full atom-economic process for the transformation of alkynes into chiral alcohols by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asymmetric hydrogenation in TFE under simple conditions has been developed. A range of chiral alcohols was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities.
引用
收藏
页码：1110 / 1113
页数：4
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