Antiandrogen blocks estrogen-induced masculinization of the song system in female zebra finches

被引:21
|
作者
Grisham, W
Lee, J
McCormick, ME
Yang-Stayner, K
Arnold, AP
机构
[1] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Lab Neuroendocrinol, Brain Res Inst, Los Angeles, CA 90095 USA
来源
JOURNAL OF NEUROBIOLOGY | 2002年 / 51卷 / 01期
关键词
song behavior; zebra finches; estradiol; Flutamide;
D O I
10.1002/neu.10028
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Song behavior and the neural song system that serves it are sexually dimorphic in zebra finches. In this species, males sing and females normally do not. The sex differences in the song system include sex differences in the proportion of neurons that express androgen receptors, which is higher in specific brain regions of males. Estradiol (E-2) administered in early development profoundly masculinizes the song system of females, including the proportion of neurons expressing androgen receptors. We examined whether or not the expression of these androgen receptors was causally related to the E-2-induced masculinization of this system by coadministering Flutamide, which blocks androgen action at the receptor, along with E-2 at hatching. E-2 alone had its usual masculinizing effect on the female song system, measured in adulthood: increasing the size of song nuclei, the size of neurons in HVC, RA, and IMAN, and the number of neurons in HVC. E-2's masculinizing action, however, was significantly diminished on all measures by coadministering Flutamide. Indeed, females receiving both E-2 and Flutamide were never significantly more masculine than controls on any measure. Flutamide alone had no effect. Our results strongly suggest that the activation of androgen receptors is necessary for the E-2-induced masculinization of the song system in females. (C) 2002 Wiley Periodicals, Inc.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 50 条
  • [21] Dynamic Gene Expression in the Song System of Zebra Finches during the Song Learning Period
    Olson, Christopher R.
    Hodges, Lisa K.
    Mello, Claudio V.
    DEVELOPMENTAL NEUROBIOLOGY, 2015, 75 (12) : 1315 - 1338
  • [22] Estrogen-induced hypospadias in the female rat
    Greene, RR
    Burrill, MW
    Ivy, AC
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1940, 43 (01): : 32 - 35
  • [23] Female zebra finches require early song exposure to prefer high-quality song as adults
    Lauay, C
    Gerlach, NM
    Adkins-Regan, E
    Devoogd, TJ
    ANIMAL BEHAVIOUR, 2004, 68 : 1249 - 1255
  • [24] ESTROGEN-INDUCED HYPERTRIGLYCERIDEMIA IN FEMALE RATS
    HILL, P
    DVORNIK, D
    CIRCULATION, 1969, 40 (4S3) : I106 - &
  • [25] Estrogen-Induced Pancreatitis in a Transgender Female
    Ranasinghe, Ushan A.
    Lim, Regine
    Jaros, Lukasz J.
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S1481 - S1481
  • [26] Reduction of female-directed song motifs induced by repeated singing in laboratory-bred zebra finches
    Botas, A
    Espino, G
    Rosenfield, DB
    Helekar, SA
    NEUROSCIENCE LETTERS, 2001, 297 (03) : 203 - 206
  • [27] Nerve growth factor effects on the song control system of zebra finches
    Fiore, M
    Patel, SN
    Alleva, E
    Aloe, L
    Clayton, NS
    NEUROSCIENCE LETTERS, 1997, 223 (03) : 161 - 164
  • [28] TrkB-like immunoreactivity in the song system of developing zebra finches
    Wade, J
    JOURNAL OF CHEMICAL NEUROANATOMY, 2000, 19 (01) : 33 - 39
  • [29] ULTRASTRUCTURAL-LOCALIZATION OF PARVALBUMIN IN THE SONG SYSTEM OPF ZEBRA FINCHES
    ZUSCHRATTER, W
    SCHEICH, H
    EXPERIENTIA, 1985, 41 (09): : 1213 - 1213
  • [30] Behavior of male and female zebra finches treated with an estrogen synthesis inhibitor as nestlings
    AdkinsRegan, E
    Yang, S
    Mansukhani, V
    BEHAVIOUR, 1996, 133 : 847 - 862