Concomitant KRAS and BRAF mutations in colorectal cancer

被引：35

作者：

Midthun, Lauren ^{[1
]}

Shaheen, Shagufta ^{[2
]}

Deisch, Jeremy ^{[3
]}

Senthil, Maheswari ^{[4
]}

Tsai, James ^{[5
]}

Hsueh, Chung-Tsen ^{[5
]}

机构：

[1] Loma Linda Univ, Dept Internal Med, Loma Linda, CA 92354 USA

[2] Stanford Med Ctr, Div Oncol, Stanford, CA USA

[3] Loma Linda Univ, Dept Pathol & Human Anat, Loma Linda, CA 92354 USA

[4] Loma Linda Univ, Dept Surg, Loma Linda, CA 92354 USA

[5] Loma Linda Univ, Div Med Oncol & Hematol, Dept Internal Med, 11175 Campus St,CSP 11015, Loma Linda, CA 92354 USA

来源：

JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2019年 / 10卷 / 03期

关键词：

BRAF; KRAS; colorectal cancer (CRC); SURVIVAL;

D O I：

10.21037/jgo.2019.01.10

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP- kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We present the clinical course of two patients with CRC harboring mutations at codon 12 of KRAS and BRAF non-V600E mutations. More research is needed to determine the clinical- pathological effect of these simultaneous mutations of KRAS and BRAF in CRC on disease course and treatment

引用

页码：577 / 581

页数：5

共 50 条

[41] Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer
Miyaki, M
Iijima, T
Yamaguchi, T
Kadofuku, T
Funata, N
Mori, T
CANCER LETTERS, 2004, 211 (01) : 105 - 109
[42] Colorectal Cancer Prognosis Is Not Associated with BRAF and KRAS Mutations-A STROBE Compliant Study
Lee, Joon-Hyop
Ahn, Jiyoung
Park, Won Seo
Choe, Eun Kyung
Kim, Eunyoung
Shin, Rumi
Heo, Seung Chul
Jung, Sohee
Kim, Kwangsoo
Chai, Young Jun
Chae, Heejoon
JOURNAL OF CLINICAL MEDICINE, 2019, 8 (01)
[43] KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: a cohort study
Negru, Serban
Papadopoulou, Eirini
Apessos, Angela
Stanculeanu, Dana Lucia
Ciuleanu, Eliade
Volovat, Constantin
Croitoru, Adina
Kakolyris, Stylianos
Aravantinos, Gerasimos
Ziras, Nikolaos
Athanasiadis, Elias
Touroutoglou, Nikolaos
Pavlidis, Nikolaos
Kalofonos, Haralabos P.
Nasioulas, George
BMJ OPEN, 2014, 4 (05):
[44] Cost-Effectiveness Analysis of Screening for KRAS and BRAF Mutations in Metastatic Colorectal Cancer
Behl, Ajay S.
Goddard, Katrina A. B.
Flottemesch, Thomas J.
Veenstra, David
Meenan, Richard T.
Lin, Jennifer S.
Maciosek, Michael V.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (23): : 1785 - 1795
[45] Frequency of KRAS/BRAF mutations as predictive markers for Cetuximab in Japanese colorectal cancer patients
Yokota, T.
Shibata, N.
Ura, T.
Takahari, D.
Shitara, K.
Muro, K.
Yatabe, Y.
EJC SUPPLEMENTS, 2009, 7 (02): : 351 - 351
[46] Double KRAS and BRAF mutations in colorectal cancer in a single oncologic department series.
Guglielmini, Pamela Francesca
Rossi, Maura
Grosso, Federica
Orecchia, Sara
Galliano, Marco
Bennicelli, Elisa
Zai, Silvia
Fusco, Vittorio
Libener, Roberta
Mariani, Narciso
Spinoglio, Giuseppe
Piovano, Pierluigi
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
[47] FUSOBACTERIUM NUCLEATUM INFECTION IS ASSOCIATED WITH BRAF/ KRAS MUTATIONS IN COLORECTAL CANCER (CRC) BUT NOT IN ADENOMAS
Koi, Minoru
Takeda, Koki
Okita, Yoshiki
Sajibu, Sija
Carethers, John M.
GASTROENTEROLOGY, 2023, 164 (06) : S987 - S987
[48] Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer
Vlad Popovici
Eva Budinska
Fred T Bosman
Sabine Tejpar
Arnaud D Roth
Mauro Delorenzi
BMC Cancer, 13
[49] Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations
Yun, Jihye
Kavalier, Adam
Roper, Jatin
Gross, Steve
Rago, Carlo
Papadopoulos, Nickolas
Vogelstein, Bert
Cantley, Lewis
CANCER RESEARCH, 2013, 73
[50] KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy
Yamane, L. S.
Scapulatempo-Neto, C.
Alvarenga, L.
Oliveira, C. Z.
Berardinelli, G. N.
Almodova, E.
Cunha, T. R.
Fava, G.
Colaiacovo, W.
Melani, A.
Fregnani, J. H.
Reis, R. M.
Guimaraes, D. P.
ONCOLOGY REPORTS, 2014, 32 (04) : 1419 - 1426

← 1 2 3 4 5 →