Binding of the influenza virus NS1 protein to model genome RNAs

被引：37

作者：

Hatada, E

Saito, S

Okishio, N

Fukuda, R

机构：

[1] KANAZAWA UNIV,SCH MED,DEPT BIOCHEM,KANAZAWA,ISHIKAWA 920,JAPAN

[2] NATL INST HLTH,DEPT VIRAL DIS & VACCINE CONTROL,LAB CYTOKINES,MUSASHIMURAYAMA,TOKYO 19012,JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1997年 / 78卷

关键词：

D O I：

10.1099/0022-1317-78-5-1059

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have previously shown that the influenza virus NS1 protein exhibits stable binding to a model mini vRNA which is stronger than its binding to dsRNA. In this study, we confirmed that the binding depended on a higher-order structure of the model RNA, probably the panhandle structure formed by pairing between the 5'- and 3'-terminal common sequences. The formation of the structure was enhanced by the NS1 protein itself. We propose that an A bulge in a stretch of double helix results in a binding site with greater affinity for the NS1 protein.

引用

页码：1059 / 1063

页数：5

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