Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells

被引：9

作者：

Luo, Di ^{[1
]}

Xie, Ji-Zhao ^{[1
]}

Zou, Lu-Hui ^{[1
]}

Qiu, Li ^{[1
]}

Huang, Dong-Ping ^{[2
]}

Xie, Yun-Feng ^{[1
]}

Xu, Huan-Ji ^{[1
]}

Wu, Xin-Duo ^{[1
]}

机构：

[1] Guangxi Med Univ, Sch Pharmaceut Sci, 22 Shuangyong Rd, Nanning 530021, Peoples R China

[2] Guangxi Med Univ, Sch Publ Hlth, 22 Shuangyong Rd, Nanning 530021, Peoples R China

来源：

PHYTOCHEMISTRY | 2020年 / 177卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma applanatum (Pers.) pat; Ganodermataceae; Lanostane-type triterpenoid; X-ray crystallographic analyses; Anti-inflammatory activity; FRUITING BODIES; CONSTITUENTS; POTENT; BODY;

D O I：

10.1016/j.phytochem.2020.112453

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five previously undescribed lanostane-type triterpenoids, including two triterpenoids with a rearranged side chain (applanoic acids E and F), one C21 nortriterpenoid (16,17-dehydroapplanone E), as well as two highly oxygenated lanostane triterpenoids (methyl applaniate B and applanoic acid G), were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography and ECD data. Applanoic acid E, 16,17-dehydroapplanone E, and methyl applaniate B showed inhibitory effects on the release of NO by LPS-induced BV-2 cells.

引用

页数：8

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