ANTI-TRYPANOSOMAL ACTIVITY OF 1,2,3,4,6-PENTA-O-GALLOYL-β-D-GLUCOSE ISOLATED FROM Plectranthus barbatus Andrews (Lamiaceae)

被引：9

作者：

dos Santos, Roberta T. ^{[1
]}

Hiramoto, Liliane L. ^{[1
]}

Lago, Joao Henrique G. ^{[1
]}

Sartorelli, Patricia ^{[1
]}

Tempone, Andre G. ^{[2
]}

Pinto, Erika G. ^{[2
,3
]}

Lorenzi, Harri ^{[4
]}

机构：

[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil

[2] Adolfo Lutz Inst, Dept Parasitol, BR-01246000 Sao Paulo, Brazil

[3] Univ Sao Paulo, Inst Med Trop Sao Paulo, BR-05403000 Sao Paulo, Brazil

[4] Inst Plantarum Estudos Flora, BR-13460000 Nova Odessa, SP, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

Plectranthus barbatus; 1,2,3,4,6-penta-O-galloyl-beta-D-glucose; anti-trypanosomal activity; ANTIMICROBIAL ABIETANE; DITERPENOIDS; ANTIBACTERIAL; CHEMOTHERAPY; PLANTS;

D O I：

10.1590/S0100-40422012001100025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 mu M, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.

引用

页码：2229 / 2232

页数：4

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