Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection

被引：12
|
作者：
Bi, Sheng [1 ]
Yao, Xin [2 ]
Huang, Cheng [1 ,3 ]
Zheng, Xia [4 ]
Xuan, Tianming [5 ]
Sheng, Jifang [1 ]
Xu, Kaijin [1 ]
Zheng, Beiwen [1 ,7 ]
Yang, Qing [6 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China
[3] Lihuili Hosp, Ningbo Med Ctr, Dept Resp Med, Ningbo, Peoples R China
[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Intens Care Unit, Hangzhou, Zhejiang, Peoples R China
[5] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiovasc, Hangzhou, Zhejiang, Peoples R China
[6] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Ctr Clin Lab, Hangzhou, Zhejiang, Peoples R China
[7] Chinese Acad Inspect & Quarantine, Inst Anim Quarantine, Beijing, Peoples R China
来源：
INFECTION | 2019年 / 47卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Carbapenem-resistance; KPC-2-producing Klebsiella pneumoniae; Tigecycline; Meropenem; Antagonistic effect; GENTAMICIN; POLYMYXIN; EFFICACY; THERAPY;
D O I：
10.1007/s15010-019-01274-w
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
IntroductionA woman infected by carbapenem-resistant Klebsiella pneumoniae is reported in this study.Case reportTigecycline and meropenem combination was used, and indeed, in vitro checkerboard synergy test confirmed the antagonism between the two antibiotics. Thus, meropenem was ceased and single high-dose tigecycline was successful against the infection. Subsequent experiments showed that the isolates of the KPC-2-producing K. pneumoniae ST11 clone caused the infection.ConclusionTherefore, tigecycline and meropenem combination should be used with caution.
引用
收藏
页码：497 / 500
页数：4
相关论文
共 50 条
  • [21] Avibactam/ceftazidimeDevelopment of resistance in KPC-producing Klebsiella pneumoniae infection: case report
    Reactions Weekly, 2020, 1792 (1) : 47 - 47
  • [22] Successful Treatment of Bloodstream Infection due to a KPC-Producing Klebsiella Pneumoniae Resistant to Imipenem/Relebactam in a Hematological Patient
    Gaibani, Paolo
    Bussini, Linda
    Amadesi, Stefano
    Bartoletti, Michele
    Bovo, Federica
    Lazzarotto, Tiziana
    Viale, Pierluigi
    Ambretti, Simone
    MICROORGANISMS, 2022, 10 (04)
  • [23] In vitro synergistic activity of meropenem/vaborbactam in combination with ceftazidime/avibactam against KPC-producing Klebsiella pneumoniae
    Gaibani, Paolo
    Ambretti, Simone
    Viale, PierLuigi
    Re, Maria Carla
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 (05) : 1457 - 1459
  • [24] In vitro Optimization of Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae
    Huang, Yanqin
    Wu, Tiffany
    Perez, Omar
    Rana, Amisha P.
    Chen, Liang
    Kreiswirth, Barry N.
    Satlin, Michael J.
    Bulman, Zackery P.
    FRONTIERS IN MICROBIOLOGY, 2021, 12
  • [25] The role of antimicrobial stewardship in preventing KPC-producing Klebsiella pneumoniae
    Carrara, Elena
    Conti, Michela
    Meschiari, Marianna
    Mussini, Cristina
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021, 76 : 12 - 18
  • [26] Hydrolytic activity of KPC-producing Klebsiella pneumoniae clinical isolates
    Tam, Vincent H.
    Hudson, Cole S.
    Merlau, Paul R.
    Shields, Ryan K.
    JOURNAL OF CHEMOTHERAPY, 2022, 34 (05) : 345 - 346
  • [27] KPC-Producing Klebsiella pneumoniae Isolates in Croatia: A Nationwide Survey
    Jelic, Marko
    Butic, Iva
    Plecko, Vanda
    Cipris, Ivan
    Jajic, Ines
    Bejuk, Danijela
    Koscak, Iva
    Marinkovic, Sonja
    Pal, Marina Payerl
    Tambic Andrasevic, Arjana
    MICROBIAL DRUG RESISTANCE, 2016, 22 (08) : 662 - 667
  • [28] Risk of transmission of KPC-producing Klebsiella pneumoniae in digestive endoscopy
    Casini, B.
    Zezza, L.
    Totaro, M.
    Giorgi, S.
    Righi, A.
    Bianchi, G.
    Marini, L.
    Valentini, P.
    Tagliaferri, E.
    Tascini, C.
    Baggiani, A.
    Privitera, G.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2016, 26 : 348 - 348
  • [29] Avibactam/ceftazidime/meropenemDevelopment of resistance in KPC-producing Klebsiella pneumoniae infection: case report
    Reactions Weekly, 2018, 1709 (1) : 42 - 42
  • [30] A LARGE OUTBREAK OF KPC-PRODUCING KLEBSIELLA PNEUMONIAE AND EFFORTS TO CONTROL IT
    Papadomichelakis, E.
    Pontikis, K.
    Matthaiopoulou, F.
    Paramythiotou, E.
    Exarhou, V.
    Karkali, E.
    Antoniadou, A.
    Giamarellou, E.
    Armaganidis, A.
    INTENSIVE CARE MEDICINE, 2009, 35 : 197 - 197
12345