Streptomyces strains producing mitochondriotoxic antimycin A found in cereal grains

被引:8
|
作者
Rasimus-Sahari, Stiina [1 ]
Mikkola, Raimo [1 ,3 ]
Andersson, Maria A. [1 ]
Jestoi, Marika [2 ]
Salkinoja-Salonen, Mirja [1 ]
机构
[1] Univ Helsinki, Dept Food & Environm Sci Microbiol, Bioctr 1,POB 56, FIN-00014 Helsinki, Finland
[2] Finnish Food Safety Author Evira, Prod Safety Unit, Mustialankatu 3, Helsinki 00790, Finland
[3] Aalto Univ, Sch Engn, Dept Civil & Struct Engn, POB 12100, Aalto 00076, Finland
基金
芬兰科学院;
关键词
Streptomyces albidoflavus; Antimycin A; Cereal grains; Mitochondriotoxic; Food safety; Enniatin B; BACILLUS-CEREUS; ALTERNATIVE OXIDASE; FUSARIUM MYCOTOXINS; IN-VITRO; FOOD; ACTINOBACTERIA; IDENTIFICATION; CYTOTOXICITY; ANTIBIOTICS; RESPIRATION;
D O I
10.1016/j.ijfoodmicro.2015.11.007
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Reasons for mammalian cell toxicity observed in barley and spring wheat grains were sought. Streptomyces sp. isolates from wheat and barley produced heat-stable methanol-soluble substances which inhibited the motility of exposed porcine spermatozoa used as a toxicity indicator. Several barley isolates produced antimycin A (2 to 5 ng/mg wet wt of biomass), a macrolide antibiotic known to block oxygen utilization in mitochondria. The antimycin-producing isolates were members of the Streptomyces albidoflavus group. In in vitro assays with porcine kidney tubular epithelial cells, the specific toxicity of antimycin A towards mitochondria was higher than that of the mycotoxin enniatin B but lower than that of the mitochondriotoxins cereulide and paenilide, produced by food-related Bacillus cereus and Paenibacillus tundrae, respectively. The toxic wheat isolates, related to Streptomyces sedi, did not produce antimycin A and or any other known toxin. Our results suggest that the presence of toxin-producing streptomycetes in stored cereal grains may pose a thus far unrecognized threat for food and feed safety. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:78 / 85
页数:8
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