HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

被引：37

作者：

Yang, Hongbing ^{[1
]}

Rei, Margarida ^{[2
]}

Brackenridge, Simon ^{[1
]}

Brenna, Elena ^{[1
]}

Sun, Hong ^{[1
,3
,4
]}

Abdulhaqq, Shaheed ^{[5
,6
]}

Liu, Michael K. P. ^{[7
]}

Ma, Weiwei ^{[7
]}

Kurupati, Prathiba ^{[2
]}

Xu, Xiaoning ^{[7
]}

Cerundolo, Vincenzo ^{[2
]}

Jenkins, Edward ^{[2
]}

Davis, Simon J. ^{[2
]}

Sacha, Jonah B. ^{[5
,6
]}

Frueh, Klaus ^{[5
,6
]}

Picker, Louis J. ^{[5
,6
]}

Borrow, Persephone ^{[1
]}

Gillespie, Geraldine M. ^{[1
]}

McMichael, Andrew J. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, NDM Res Bldg, Oxford OX3 7FZ, England

[2] Univ Oxford, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford OX3 9DS, England

[3] China Med Univ, Dept Lab Med, Key Lab AIDS Immunol, Affiliated Hosp 1, Shenyang, Peoples R China

[4] Univ Oxford, Chinese Acad Med Sci, Oxford Inst, NDM, Oxford, England

[5] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Beaverton, OR 97006 USA

[6] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA

[7] Imperial Coll, Chelsea & Westminster Hosp, Ctr Immunol & Vaccinol, London, England

来源：

SCIENCE IMMUNOLOGY | 2021年 / 6卷 / 57期

基金：

英国惠康基金;

关键词：

HIGHLY PATHOGENIC SIV; ANTIGEN; EXPRESSION; REPERTOIRE; RECEPTORS; COMPLEXES; EXPANSION; RESPONSES; PEPTIDES; LIGAND;

D O I：

10.1126/sciimmunol.abg1703

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infected individuals. Here, HLA-E-restricted, HIV-1-specific CD8(+) T cells were primed in vitro. These T cell clones and allogeneic CD8(+) T cells transduced with their T cell receptors suppressed HIV-1 replication in CD4(+) T cells in vitro. Vaccine induction of efficacious HLA-E-restricted HIV-1-specific T cells should therefore be possible.

引用

页数：11

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