A New Study on (2S, 3S)-1,4-bis-Sulfanylbutane-2,3-diol

被引：0
|
作者：
Toader, Corina [2 ]
Baciu, Ion [1 ]
Zarafu, Irina [1 ]
机构：
[1] Univ Bucharest, Fac Chem, Bucharest 050663, Romania
[2] Marius Nasta Natl Inst Pneumol, Bucharest 050159, Romania
来源：
REVISTA DE CHIMIE | 2009年 / 60卷 / 09期
关键词：
reduction agent; dithiothreitol (DTT); M; tuberculosis; BIOLOGICAL-ACTIVITY; SALTS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The objective of this study was to assess the performance of dithiothreitol ((2S,3S)-1,4-bis-sulfanylbutane-2,3-diol] - NaOH digestion-decontamination procedure versus N-acetyl-L-cysteine (NALC) - NaOH method in detection and recovery of M. tuberculosis in clinical practice. The study was made of two independent procedures. Each procedure used a different specimen processing method. For one procedure, all specimens were processed with DTT - NaOH, and for the other, all specimens were processed with NALC - NaOH. DTT - NaOH specimen processing method was compared with NALC - NaOH method. Processed sediments were split for analysis by fluorescente smear microscopy and by culture using solid media. A total of 823 sputum were processed in the DTT-NaOH procedure of the study and a total of 865 sputum were processed for NALC-NaOH procedure of the study. Statistical comparisons of the procedures were done and the implications of the results are discussed. Dithiothreitol sputum processing significantly increased the smear sensitivity.
引用
收藏
页码：909 / 914
页数：6
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