Solubility of 1,3-Dimethyl-7H-purine-2,6-dione (Theophylline) in Supercritical Carbon Dioxide

被引：4
|
作者：
de la Fuente, Juan C. [1 ]
Nunez, Gonzalo [2 ]
del Valle, Jose M. [2 ]
机构：
[1] Univ Tecn Federico Santa Maria, Dept Ingn Quim & Ambiental, Valparaiso, Chile
[2] Pontificia Univ Catolica Chile, Dept Ingn Quim & Bioproc, Santiago, Chile
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2009年 / 54卷 / 11期
关键词：
LIQUID-CHROMATOGRAPHY; PHASE-BEHAVIOR; THEOBROMINE; CAFFEINE; CO2;
D O I：
10.1021/je900099m
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
This contribution provides complementary experimental data of solubility (y(2), molar fraction) of solid 1,3-dimethyl-7H-purine-2,6-dione (theophylline) in supercritical CO2 as a function of temperature (313 K <= T <= 333 K) and pressure (10 MPa <= P <= 44 MPa). A static-analytic methodology was used with standard deviations from average solubility measurements of <= 38% and with estimated inherit errors <= 25%. The solubility of theophylline increased with the CO2 density from 0.33.10(-5) mol.mol(-1) at 797.2 kg.m(-3) (313 K, 16 MPa) to 3.3.10(-5) mol.mol(-1) at 890.2 kg.m(-3) (333 K, 40 MPa). The solubility increased with pressure and temperature. Experimental solubilities were correlated with a density-based model with three adjustable parameters, which was valid for solvent densities in the range of (400 to 950) kg.m(-3).
引用
收藏
页码：3034 / 3036
页数：3
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