Bipolar disorder;
Elderly;
Geriatric;
Early onset;
Treatment;
Dementia;
D O I:
10.1007/s11920-020-01216-6
中图分类号:
R749 [精神病学];
学科分类号:
100205 ;
摘要:
Purpose of ReviewWith more individuals reaching older ages, bipolar disorder is no longer a rare illness in the elderly. Despite the growing number of the older individuals with the illness, there are few studies that focus on bipolar disorder in the geriatric population leading to gaps in clinical knowledge and treatment. The aim of this study is therefore to increase understanding by summarizing the available literature on the epidemiology, symptomatology, comorbidities, and treatment recommendations in this cohort, as well as to suggest areas for future clinical and research focus.Recent FindingsThe prevalence of bipolar disorder is underestimated in the geriatric population. The illness maintains the main features observed in the other cohorts but it also has some specific characteristics in the older individuals. In this cohort, psychiatric and medical comorbidities tend to be the rule rather than the exception. Higher rates of cognitive impairments than age- and education-matched groups present across all of the illness phases. Treatment is more challenging in the elderly individuals due to higher rates of comorbidities and susceptibility to medication side effects. Two cohorts of older individuals with bipolar disorder can be recognized, those with symptoms that start earlier in life and those with late-life onset.SummaryAlthough the knowledge about elderly bipolar disorder is only slowly growing, it is increasingly recognized as an illness with unique features. More work is needed to improve diagnosis and to establish treatment guidelines.
机构:
Parnassia Psychiat Inst, Bavo Europoort, Dept Old Age Psychiat, Rotterdam, NetherlandsParnassia Psychiat Inst, Bavo Europoort, Dept Old Age Psychiat, Rotterdam, Netherlands
Soebhag, Wenika
Oostervink, Frits
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机构:
GGZ Haagstreek Rivierduinen, Dept Old Age Psychiat, Leidschendam, NetherlandsParnassia Psychiat Inst, Bavo Europoort, Dept Old Age Psychiat, Rotterdam, Netherlands
Oostervink, Frits
Groeneweg, Isis
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机构:
Parnassia Psychiat Inst, Bavo Europoort, Dept Old Age Psychiat, Rotterdam, NetherlandsParnassia Psychiat Inst, Bavo Europoort, Dept Old Age Psychiat, Rotterdam, Netherlands
Groeneweg, Isis
Kok, Rob
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机构:
Parnassia Psychiat Inst, Dept Old Age Psychiat, The Hague, NetherlandsParnassia Psychiat Inst, Bavo Europoort, Dept Old Age Psychiat, Rotterdam, Netherlands
机构:
Univ Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, Brazil
Zung, Stevin
Cordeiro, Quirino
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机构:
Univ Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, Brazil
Cordeiro, Quirino
Lafer, Beny
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机构:
Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, Brazil
Lafer, Beny
Nascimento, Andreia De Fatima
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机构:
Univ Sao Paulo, Med Sch, Santa Casa Sch Med Sci Sao Paulo, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, Brazil
Nascimento, Andreia De Fatima
Vallada, Homero
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机构:
Univ Sao Paulo, Univ London, Kings Coll, Med Sch, Sao Paulo, Brazil
Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, Med Invest Lab LIM 23, Sao Paulo, Brazil