One-Pot Reductive N-Alkylation with Carbonyl Compounds To Give Tertiary Amines via Borane Reduction of Imines

被引：16

作者：

Tokizane, Masashi ^{[2
]}

Sato, Kaori ^{[2
]}

Sakami, Yuki ^{[2
]}

Imori, Yoichiro ^{[2
]}

Matsuo, Chika ^{[2
]}

Ohta, Tetsuo ^{[1
]}

Ito, Yoshihiko ^{[2
]}

机构：

[1] Doshisha Univ, Fac Life & Med Sci, Dept Biomed Informat, Kyoto 6100394, Japan

[2] Doshisha Univ, Fac Engn, Dept Mol Sci & Technol, Kyoto 6100394, Japan

来源：

SYNTHESIS-STUTTGART | 2010年 / 01期

关键词：

reductive N-alkylation; borane reduction; imines; tertiary amines; one-pot reaction; SECONDARY-AMINES; AMINATION; ALDEHYDES; KETONES; COMPLEX; REAGENTS; PYRIDINE; SOLVENT;

D O I：

10.1055/s-0029-1217076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot synthesis of tertiary amines via borane-mediated reduction of imines and reductive N-alkylation with carbonyl compounds is described. This protocol's reducing agent is only borane in the reduction of imines, and additional reductant is not necessary in reductive N-alkylation step. When using more than two equivalents of aldehydes, reductive N-alkylation proceeded in good yield.

引用

页码：36 / 42

页数：7

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