Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia

被引：1

作者：

Alexopoulos, Panagiotis ^{[1
,2
]}

Thierjung, Nathalie ^{[1
]}

Economou, Polychronis ^{[3
]}

Werle, Lukas ^{[1
,4
]}

Buhl, Felix ^{[1
]}

Kagerbauer, Simone ^{[5
]}

Papanastasiou, Anastasios D. ^{[6
]}

Grimmer, Timo ^{[1
]}

Gourzis, Philippos ^{[2
]}

Berthele, Achim ^{[7
]}

Hemmer, Bernhard ^{[7
,8
]}

Kuebler, Hubert ^{[9
]}

Martin, Jan ^{[5
]}

Politis, Antonios ^{[10
,11
]}

Perneczky, Robert ^{[8
,12
,13
,14
]}

机构：

[1] Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

[2] Univ Patras, Univ Hosp Rion, Dept Psychiat, Patras, Greece

[3] Univ Patras, Dept Civil Engn Stat, Patras, Greece

[4] Max Planck Inst Psychiat, Munich, Germany

[5] Tech Univ Munich, Dept Anaesthesiol, Klinikum Rechts Isar, Munich, Germany

[6] Univ Patras, Mol Oncol Lab, Div Oncol, Univ Hosp Patras, Patras, Greece

[7] Tech Univ Munich, Dept Neurol, Klinikum Rechts Isar, Munich, Germany

[8] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[9] Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany

[10] Univ Athens, Dept Psychiat 1, Eginit Hosp, Athens, Greece

[11] Johns Hopkins Med Sch, Dept Psychiat, Div Geriatr Psychiat & Neuropsychiat, Baltimore, MD USA

[12] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany

[13] Imperial Coll Sci Technol & Med, Ageing Epidemiol AGE Res Unit, Sch Publ Hlth, Fac Med, London, England

[14] German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 69卷 / 01期

关键词：

Biomarker candidate; NIA-AA research framework diagnostic criteria; soluble amyloid-beta protein precursor beta; CEREBROSPINAL-FLUID BIOMARKERS; AMYLOID PRECURSOR PROTEINS; MILD COGNITIVE IMPAIRMENT; BACE1; ACTIVITY; CSF; BETA-AMYLOID((1-42)); METABOLISM; CLEARANCE; DECLINE; MARKERS;

D O I：

10.3233/JAD-181088

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cost- and time-effective markers of Alzheimer's disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-beta protein precursor beta (sA beta PP beta) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sA beta PP beta levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N = 33) are significantly lower (p < 0.01) than those of cognitively healthy elderly individuals without AD (N = 39), while CSF sA beta PP beta levels did not differ between the studied groups. This provides further evidence for the potential of sA beta PP beta in plasma as an AD biomarker candidate.

引用

页码：83 / 90

页数：8

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