The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

被引：20
|
作者：
Gekara, Nelson O. [1 ,2 ]
Jiang, Hui [2 ]
机构：
[1] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden
[2] Umea Univ, Lab Mol Infect Med Sweden MIMS, Umea Ctr Microbial Res, S-90187 Umea, Sweden
来源：
SCIENCE SIGNALING | 2019年 / 12卷 / 581期
基金：
瑞典研究理事会;
关键词：
D O I：
10.1126/scisignal.aax3521
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.
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页数：2
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