Receptor mediated subversion of macrophage cytokine production by intracellular pathogens

被引：49

作者：

Mosser, DM ^{[1
]}

Karp, CL

机构：

[1] Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Immunol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(99)80068-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited by intracellular pathogens of macrophages to inhibit IL-12 production and delay or prevent the development of cell mediated immunity.

引用

页码：406 / 411

页数：6

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