Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes

被引：5

作者：

Koakutsu, Tomoaki ^{[1
,2
]}

Nomura, Ryosuke ^{[2
]}

Yamanouchi, Satoshi ^{[2
]}

Kushimoto, Shigeki ^{[2
]}

Itoi, Eiji ^{[1
]}

Shinozawa, Yotaro ^{[3
]}

机构：

[1] Tohoku Univ Hosp, Dept Orthopaed Surg, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ Hosp, Emergency Ctr, Sendai, Miyagi 9808574, Japan

[3] Int Univ Hlth & Welf Hosp, Dept Emergency Med, Nasushiobara, Japan

来源：

UPSALA JOURNAL OF MEDICAL SCIENCES | 2013年 / 118卷 / 01期

关键词：

Necrotizing soft tissue infection; oxygen free radical; antioxidant status; SEPSIS; MODEL; BILIRUBIN; MORTALITY; DAMAGE; RISK;

D O I：

10.3109/03009734.2012.733738

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacron-reactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections.

引用

页码：46 / 50

页数：5

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