Synthesis of isoquinolone via rhodium(III)-catalyzed C-H activation with 1,4,2-dioxazol-5-ones as oxidizing directing group

被引：15

作者：

Zhu, Huajian ^{[1
]}

Zhuang, Rangxiao ^{[2
]}

Zheng, Wenya ^{[1
]}

Fu, Liping ^{[3
]}

Zhao, Yuanke ^{[1
]}

Tu, Luping ^{[1
]}

Chai, Yitao ^{[1
]}

Zeng, Linghui ^{[1
]}

Zhang, Chong ^{[1
]}

Zhang, Jiankang ^{[1
]}

机构：

[1] Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China

[2] Hangzhou Xixi Hosp, Dept Pharmaceut Preparat, Hangzhou 310023, Zhejiang, Peoples R China

[3] Shaoxing Hosp Tradit Chinese Med, Dept Pharm, Shaoxing 312000, Zhejiang, Peoples R China

来源：

TETRAHEDRON | 2019年 / 75卷 / 23期

基金：

美国国家科学基金会;

关键词：

1,4,2-Dioxazol-5-ones; Rhodium(III)-catalyzed; C-H activation; Oxidizing directing groups; Isoquinolones; OXIDATIVE ANNULATION; CATALYZED SYNTHESIS; INTERNAL OXIDANT; DIRECT ACCESS; O BOND; BENZAMIDES; AMIDATION; ACTIVATION/ANNULATION; CYCLOADDITION; ALKENYLATION;

D O I：

10.1016/j.tet.2019.04.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient rhodium-catalyzed direct C-H activation for the synthesis of isoquinolone with 1,4,2-dioxazol-5-ones as oxidizing directing groups have been developed, which featured mild reaction conditions, short reaction time and satisfactory yield. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：3108 / 3112

页数：5

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