Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y 12 deficiencies

被引：1

作者：

Lunghi, Barbara ^{[1
]}

Lecchi, Anna ^{[2
]}

Santacroce, Rosa ^{[3
]}

Scavone, Mariangela ^{[4
]}

Paniccia, Rita ^{[5
]}

Artoni, Andrea ^{[2
]}

Gachet, Christian ^{[6
]}

Castaman, Giancarlo ^{[5
]}

Margaglione, Maurizio ^{[3
]}

Bernardi, Francesco ^{[1
]}

Cattaneo, Marco ^{[4
,7
]}

机构：

[1] Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy

[2] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, Milan, Italy

[3] Univ Foggia, Dept Clin & Expt Med, Med Genet, Foggia, Italy

[4] Univ Milan, Dipartimento Sci Salute, Milan, Italy

[5] Careggi Univ Hosp, Dept Oncol, Ctr Bleeding Disorders & Coagulat, Florence, Italy

[6] Univ Strasbourg, INSERM, EFS Grand Est, BPPS,UMR S 1255,FMTS, Strasbourg, France

[7] Presidio San Paolo, ASST Santi Paolo & Carlo, Unita Med, Milan, Italy

来源：

HAEMATOLOGICA | 2020年 / 105卷 / 07期

关键词：

ACTIVATION; RASGRP2;

D O I：

10.3324/haematol.2019.232850

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E361 / E364

页数：4

共 41 条

[31] Co-activation of P2Y1 and P2TAC receptors and subsequent platelet aggregation are essential for ADP-induced thromboxane A2 generation in human platelets
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[32] Patients with congenital abnormality of platelet aggregation induced by Ca2+ ionophores may have a defect of the platelet P2Y12 receptor for ADP -: Reply
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[33] ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay: influence of low HDL
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EUROPEAN HEART JOURNAL, 2008, 29 : 673 - 673
[34] Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1
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Heptinstall, S
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[35] Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects
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CIRCULATION, 2003, 108 (08) : 989 - 995
[36] Effects of pharmacological inhibition of the P2Y1 and P2Y12 ADP receptors on shear-induced platelet aggregation and platelet thrombus formation on a collagen-coated surface under flow conditions
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DRUG DEVELOPMENT RESEARCH, 2002, 56 (04) : 565 - 565
[37] Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin
Storey, RF
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Heptinstall, S
THROMBOSIS AND HAEMOSTASIS, 2002, 88 (03) : 488 - 494
[38] Effects of pharmacological inhibition of the P2Y1 and P2Y12 ADP receptors on shear-induced platelet aggregation and platelet thrombus formation on a collagen-coated surface under flow conditions.
Cattaneo, M
Savage, B
Ruggeri, ZM
BLOOD, 2001, 98 (11) : 239A - 240A
[39] Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3
Storey, Robert F.
Thornton, S. Melissa
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Husted, Steen
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Heptinstall, Stan
Armstrong, Martin
PLATELETS, 2009, 20 (05) : 341 - 348
[40] AZD6140 displays over 100-fold higher affinity for the P2Y12 receptor vs AZ11702105, a chemical compound indistinguishable from the active metabolite of prasugrel, and is a more potent inhibitor of ADP-induced platelet aggregation
van Giezen, Joseph J.
Berntsson, Pia S.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (06) : E139 - E140

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