Anti-Hypertensive Drug Felodipine Exerts Influence on the Metabolism of Serotonin

被引：0
|
作者：
Huang, Qing [1 ]
Huang, Weijian [2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Cixi Hosp, Cixi 315300, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2018年 / 37卷 / 03期
关键词：
anti-hypertensive drug; felodipine; serotonin; UDP-GLUCURONOSYLTRANSFERASES UGTS; HYPERTENSION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Felodipine, a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b, is clinically employed to treat mild to moderate essential hypertension. This study aims to determine the inhibition of felodipine on the activity of UDP-glucuronosyltransferase (UGT) 1A6 which is the main enzyme catalyzing the metabolic elimination of serotonin. 100 mu M of felodipine was used as the initial screening concentration to determine the inhibition of felodipine on the activity of UGT1A6, and approximately 100% activity of UGT1A6 was inhibited by 100 mu M of felodipine. Taken together, our recent study gave a rapid report demonstrating the inhibition of anti-hypertensive drug felodipine on the metabolism of serotonin.
引用
收藏
页码：596 / 598
页数：3
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