Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S

被引：2

作者：

Bremm, Anja ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Fac Med, Inst Biochem 2, Theodor Stern Kai 7, D-60590 Frankfurt, Germany

来源：

SCIENCE SIGNALING | 2020年 / 13卷 / 654期

关键词：

COMPLEX;

D O I：

10.1126/scisignal.abd9892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Precise control of the activity and abundance of ubiquitin-conjugating enzymes (E2s) ensures fidelity in ubiquitin chain synthesis. In this issue of Science Signaling, Liess et al. demonstrate that the human anaphase-promoting complex (APC/C)-associated E2 UBE2S adopts an autoinhibited dimeric state that increases the half-life of UBE2S by preventing its autoubiquitination-driven turnover.

引用

页数：2

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