Synthesis of 2′-O-(2-acetamide) purine and pyrimidine nucleosides and the antisense properties of the modified oligonucleotides.

被引:0
|
作者
Kawasaki, A [1 ]
Fraser, AS [1 ]
Prakash, TP [1 ]
Cook, PD [1 ]
Manoharan, M [1 ]
机构
[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
45-CARB
引用
收藏
页码:U194 / U194
页数:1
相关论文
共 50 条
  • [21] Antisense properties of 2′-O-dimethylaminooxyethyl (2′-O-DMAOE) oligonucleotides
    Prakash, TP
    Kawasaki, AM
    Johnston, JF
    Graham, MJ
    Condon, TP
    Manoharan, M
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20 (4-7): : 829 - 832
  • [22] Synthesis of antisense oligonucleotides carrying modified 2-5A molecules at their 5′-termini and their properties
    Ueno, Y
    Kato, Y
    Okatani, S
    Ishida, N
    Nakanishi, M
    Kitade, Y
    BIOCONJUGATE CHEMISTRY, 2003, 14 (03) : 690 - 696
  • [23] SYNTHESIS AND CONFORMATIONAL PROPERTIES OF 2'-DEOXY-2'-METHYLTHIOPYRIMIDINE AND 2'-DEOXY-2'-METHYLTHIO-PURINE NUCLEOSIDES - POTENTIAL ANTISENSE APPLICATIONS
    FRASER, A
    WHEELER, P
    COOK, PD
    SANGHVI, YS
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (05) : 1277 - 1287
  • [24] Synthesis of (2′S)- and (2′R)-2′-deoxy-2′-[(2-methoxyethoxy)amino] pyrimidine nucleosides and oligonucleotides
    Zatsepin, TS
    Ivanova, YM
    Oretskaya, TS
    CHEMISTRY & BIODIVERSITY, 2004, 1 (10) : 1537 - 1545
  • [25] Synthesis of high affinity antisense oligonucleotides with 2'-sugar modified 2-thiopyrimidines.
    Rajeev, KG
    Prakash, TP
    Lesnik, E
    Manoharan, M
    Swayze, EE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U260 - U260
  • [26] Synthesis and Properties of Modified Oligodeoxyribonucleotides Containing 2"-O-(2,3-Dihydroxypropyl)uridine and 2"-O-(2-Oxoethyl)uridine
    T. S. Zatsepin
    A. V. Kachalova
    E. A. Romanova
    D. A. Stetsenko
    M. J. Gait
    T. S. Oretskaya
    Russian Journal of Bioorganic Chemistry, 2001, 27 : 39 - 44
  • [27] Synthesis and properties of modified oligodeoxyribonucleotides containing 2′-O-(2,3-dihydroxypropyl)uridine and 2′-O-(2-oxoethyl)uridine
    Zatsepin, TS
    Kachalova, AV
    Romanova, EA
    Stetsenko, DA
    Gait, MJ
    Oretskaya, TS
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2001, 27 (01) : 39 - 44
  • [28] SYNTHESIS AND HYBRIDIZATION PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 2'-O-MODIFIED RIBONUCLEOTIDES
    KELLER, TH
    HANER, R
    NUCLEIC ACIDS RESEARCH, 1993, 21 (19) : 4499 - 4505
  • [29] SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRIMIDINE AND PURINE ALPHA-L-2',3'-DIDEOXY NUCLEOSIDES
    VANDRAANEN, NA
    KOSZALKA, GW
    NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (08): : 1679 - 1693
  • [30] Direct comparison of in vivo antisense activity of ENA oligonucleotides targeting PTP1B mRNA with that of 2′-O-(2-methoxy)ethyl-modified oligonucleotides
    Koizumi, Makoto
    Takagi-Sato, Miho
    Okuyama, Ryo
    Araki, Kazushi
    Sun, Weiyong
    Nakai, Daisuke
    Tsutsumi, Shinya
    Kawai, Kenji
    OLIGONUCLEOTIDES, 2006, 16 (03) : 253 - 262