Benzyl alcohol inhibits N-methyl-D-aspartate receptor-mediated neurotoxicity and calcium accumulation in cultured rat cortical neurons

被引：4
|
作者：
Takadera, Tsuneo [1 ]
Ohyashiki, Takao [1 ]
机构：
[1] Hokuriku Univ, Fac Pharmaceut Sci, Dept Clin Chem, Kanazawa, Ishikawa 9201181, Japan
来源：
JOURNAL OF BIOMEDICAL SCIENCE | 2008年 / 15卷 / 06期
关键词：
N-methyl-D-aspartate receptor; Benzyl alcohol; Calcium; Cell death; Cortical cells;
D O I：
10.1007/s11373-008-9276-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The purpose of this study is to examine whether benzyl alcohol affects N-methyl-D-aspartate (NMDA) receptor in cortical cells. Benzyl alcohol (0.5-2 mM) inhibited NMDA-induced cytotoxicity. The protective effect of benzyl alcohol on NMDA-induced toxicity disappeared by washing cells with buffer to remove benzyl alcohol. Benzyl alcohol reduced NMDA receptor-mediated calcium accumulation, indicating that benzyl alcohol inhibits NMDA receptor activity.
引用
收藏
页码：767 / 770
页数：4
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