Fitusiran, an Investigational RNAi Therapeutic Targeting Antithrombin for the Treatment of Hemophilia: Updated Results from a Phase 1 and Phase 1/2 Extension Study in Patients with Inhibitors

被引:8
|
作者
Pasi, K. John [1 ]
Georgiev, Pencho [2 ]
Mant, Tim [3 ]
Lissitchkov, Toshko [4 ]
Creagh, Michael Desmond [5 ]
Bevan, David [6 ]
Austin, Steve [7 ]
Hay, Charles R. [8 ]
Hegemann, Inga [9 ]
Kazmi, Rashid [10 ]
Chowdary, Pratima [11 ,12 ]
Ragni, Margaret V. [13 ,14 ]
Soh, Chang-Heok [15 ]
Akinc, Akin [15 ]
Partisano, Angela M. [15 ]
Sorenson, Benny [15 ]
Rangarajan, Savita [16 ]
机构
[1] Barts & London Queen Marys Sch Med & Dent, Royal London Haemophilia Ctr, London, England
[2] Univ Multiprofile Hosp Act Treatment Sveti Georgi, Plovdiv, Bulgaria
[3] Quintiles Drug Res Unit, London, England
[4] SHAT Joan Pavel, Dept Coagulat Disorders & Anemia, Sofia, Bulgaria
[5] Royal Cornwall Hosp NHS Trust, Truro, England
[6] Guys & St Thomas Hosp NHS Trust, London, England
[7] St Georges Univ Hosp NHS Fdn Trust, St Georges Haemophilia Ctr, London, England
[8] Manchester Royal Infirm, Manchester, Lancs, England
[9] Univ Hosp, Zurich, Switzerland
[10] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England
[11] Royal Free Hosp, KD Haemophilia Ctr, London, England
[12] Royal Free Hosp, Thrombosis Unit, London, England
[13] Univ Pittsburgh, Div Hematol Oncol, Dept Med, Med Ctr, Pittsburgh, PA USA
[14] Univ Pittsburgh, Hemophilia Ctr Western PA, Med Ctr, Pittsburgh, PA USA
[15] Alnylam Pharmaceut, Cambridge, MA USA
[16] Guys & St Thomas NHS Fdn Trust, Ctr Haemostasis Thrombosis, London, England
关键词
D O I
10.1182/blood.V128.22.1397.1397
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1397
引用
收藏
页数:6
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