IMMUNE RESPONSE IN HIV EPIDEMICS FOR DISTINCT TRANSMISSION RATES AND FOR SATURATED CTL RESPONSE

被引:14
|
作者
Carvalho, Ana R. M. [1 ]
Pinto, Carla M. A. [2 ]
机构
[1] Univ Porto, Fac Sci, Rua Campo Alegre S-N, P-4440452 Porto, Portugal
[2] Univ Porto, Ctr Math, Polytech Porto, Sch Engn, Rua Dr Antonio Bernardino de Almeida 431, P-4249015 Porto, Portugal
关键词
HIV infection; disease transmission rates; saturated CTL response; fractional model; FRACTIONAL CALCULUS; INFECTION; MODEL; DYNAMICS; VACCINATION; IMPACT; CELLS;
D O I
10.1051/mmnp/2019007
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this paper, we study the immune response in a fractional order model for HIV dynamics, for distinct disease transmission rates and saturated cytotoxic T-lymphocyte (CTL) response. Our goal is twofold: (i) to analyze the role of the order of the fractional derivative, alpha, on the efficacy of the immune response, (ii) to examine the immune response for distinct transmission functions, in the presence of saturated CTL response. We compute the reproduction number of the model and state the stability of the disease-free equilibrium. We discuss the results of the model from an epidemiological point of view.
引用
收藏
页数:13
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