Executive summary of the diagnosis and antimicrobial treatment of invasive infections due to multidrug-resistant Enterobacteriaceae. Guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)

被引：9

作者：

Rodriguez-Bano, Jesus ^{[1
,2
,3
]}

Miguel Cisneros, Jose ^{[1
,2
,4
]}

Cobos-Trigueros, Nazaret ^{[5
]}

Fresco, Gema ^{[6
]}

Navarro-San Francisco, Carolina ^{[7
]}

Gudiol, Carlota ^{[8
]}

Pablo Horcajada, Juan ^{[9
]}

Lopez-Cerero, Lorena ^{[1
,2
]}

Antonio Martinez, Jose ^{[5
]}

Molina, Jose ^{[1
,2
]}

Montero, Milagro ^{[9
]}

Pano-Pardo, Jose R. ^{[7
]}

Pascual, Alvaro ^{[1
,2
,10
]}

Pena, Carmen ^{[8
]}

Pintado, Vicente ^{[6
]}

Retamar, Pilar ^{[1
,2
]}

Tomas, Maria ^{[11
]}

Borges-Sa, Marcio ^{[12
]}

Garnacho-Montero, Jose ^{[4
,13
]}

Bou, German ^{[11
]}

机构：

[1] Hosp Univ Virgen Macarena, Unidad Clin Interctr Enfermedades Infecciosas Mic, Seville, Spain

[2] Hosp Univ Virgen del Rocio, Unidad Clin Interctr Enfermedades Infecciosas Mic, Seville, Spain

[3] Univ Seville, Dept Med, Seville, Spain

[4] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBiS, Seville, Spain

[5] Hosp Clin Barcelona, Serv Enfermedades Infecciosas, Barcelona, Spain

[6] Hosp Univ Ramon & Cajal, Serv Enfermedades Infecciosas, Madrid, Spain

[7] Hosp Univ La Paz, Unidad Enfermedades Infecciosas, Madrid, Spain

[8] Hosp Univ Bellvitge, ICO, Serv Enfermedades Infecciosas, Barcelona, Spain

[9] Hosp Univ del Mar, Inst Hosp del Mar Invest Med IMIM, Serv Enfermedades Infecciosas, Barcelona, Spain

[10] Univ Seville, Dept Microbiol, Seville, Spain

[11] Complejo Hosp Univ A Coruna, Microbiol Serv, La Coruna, Spain

[12] Hosp Son Llatzer, Serv Med Intens, Palma De Mallorca, Spain

[13] Hosp Univ Virgen del Rocio, Unidad Clin Cuidados Crit & Urgencias, Seville, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2015年 / 33卷 / 05期

关键词：

Guidelines Multidrug-resistant Enterobacteriaceae; Carbapenemases; Extended-spectrum beta-lactamase; Therapy;

D O I：

10.1016/j.eimc.2014.11.015

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum beta-lactamases (ESBL) and carbapenemases is a serious public health problem worldwide. Microbiological diagnosis and therapy of these infections are challenging and controversial. After the selection of clinically relevant questions, this document provides evidence-based recommendations for the use of microbiological techniques for the detection of ESBL- and carbapenemase-producing Enterobacteriaceae, and for antibiotic therapy for invasive infections caused by these organisms. The absence of randomized-controlled trials is noteworthy, thus recommendations are mainly based on observational studies, that have important methodological limitations, pharmacokinetic and pharmacodynamics models, and data from animal studies. Additionally, areas for future research were identified. (C) 2014 Elsevier Espana, S.L.U. and Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.

引用

页码：338 / 341

页数：4

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