Discovery and preclinical evaluation of a novel highly selective and potent CDK12 inhibitor.

被引:0
|
作者
Yamakawa, Hiroko [1 ]
Mizutani, Akio [1 ]
Arikawa, Yasuyoshi [1 ]
Ebara, Shunsuke [1 ]
Satoh, Yoshihiko [1 ]
Morishita, Daisuke [1 ]
机构
[1] Chordia Therapeut Inc, Fujisawa, Japan
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5485
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
    Walsh, Shawn P.
    Shahripour, Aurash
    Tang, Haifeng
    Teumelsan, Nardos
    Frie, Jessica
    Zhu, Yuping
    Priest, Birgit T.
    Swensen, Andrew M.
    Liu, Jessica
    Margulis, Michael
    Visconti, Richard
    Weinglass, Adam
    Felix, John P.
    Brochu, Richard M.
    Bailey, Timothy
    Thomas-Fowlkes, Brande
    Alonso-Galicia, Magdalena
    Zhou, Xiaoyan
    Pai, Lee-Yuh
    Corona, Aaron
    Hampton, Caryn
    Hernandez, Melba
    Bentley, Ross
    Chen, Jing
    Shah, Kashmira
    Metzger, Joseph
    Forrest, Michael
    Owens, Karen
    Tong, Vincent
    Ha, Sookhee
    Roy, Sophie
    Kaczorowski, Gregory J.
    Yang, Lihu
    Parmee, Emma
    Garcia, Maria L.
    Sullivan, Kathleen
    Pasternak, Alexander
    ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (07): : 747 - 752
  • [22] Discovery of a potent and selective Axl inhibitor in preclinical model
    Inoue, Satoshi
    Yamane, Yoshinobu
    Tsukamoto, Shuntaro
    Azuma, Hiroshi
    Nagao, Satoshi
    Murai, Norio
    Nishibata, Kyoko
    Fukushima, Sayo
    Ichikawa, Kenji
    Nakagawa, Takayuki
    Sugi, Naoko Hata
    Ito, Daisuke
    Kato, Yu
    Goto, Aya
    Kakiuchi, Dai
    Ueno, Takashi
    Matsui, Junji
    Matsushima, Tomohiro
    BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 39
  • [23] Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models
    Li Wang
    Chen Hu
    Aoli Wang
    Cheng Chen
    Jiaxin Wu
    Zongru Jiang
    Fengming Zou
    Kailin Yu
    Hong Wu
    Juan Liu
    Wenliang Wang
    Zuowei Wang
    Beilei Wang
    Ziping Qi
    Qingwang Liu
    Wenchao Wang
    Lili Li
    Jian Ge
    Jing Liu
    Qingsong Liu
    Investigational New Drugs, 2020, 38 : 1272 - 1281
  • [24] Structure-based design of potent CDK4 selective inhibitor.
    Honma, T
    Hayashi, K
    Kawanishi, N
    Yoshizumi, T
    Hashimoto, N
    Sugimoto, T
    Nakamura, K
    Takaki, T
    Machida, T
    Fukasawa, K
    Hirai, H
    Iwama, T
    Ikeura, C
    Ikuta, M
    Kamata, K
    Suzuki-Takahashi, I
    Hayama, T
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U24 - U24
  • [25] Current progress and novel strategies that target CDK12 for drug discovery
    Lei, Peng
    Zhang, Jifa
    Liao, Peiyu
    Ren, Changyu
    Wang, Jiaxing
    Wang, Yuxi
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 240
  • [26] Preclinical disposition and pharmacokinetics of volitinib, a novel selective cMet inhibitor.
    Gu, Yi
    Sai, Yang
    Wang, Jian
    Xia, Sumei
    Wang, Guanglin
    Zhao, Yuansheng
    Zhang, Li
    Yang, Wenqing
    Dai, Guangxiu
    Zhang, Weihan
    Gong, Qisun
    Tian, Zhenping
    Su, Weiguo
    CANCER RESEARCH, 2013, 73 (08)
  • [27] Preclinical evaluation of TQB3616, a highly potent and selective small-molecule CDK4/6 inhibitor
    Xu Zhaobing
    Hu Lihong
    Liu Yingchun
    Ding, Charles Z.
    Zhu, Xiaoyu
    Chen, Chen
    Zhu, Yusong
    Wu, Jiahu
    Wu, Dongdong
    Chen, Shuhui
    Zhang, Xiquan
    Yang, Ling
    Tian, Xin
    CANCER RESEARCH, 2018, 78 (13)
  • [28] Preclinical development of a highly potent and selective dual inhibitor of CDK4/6 for the treatment of cancer
    Bantie, Laychiluh
    Tadesse, Solomon
    Likisa, Jimma
    Yu, Mingfeng
    Noll, Benjamin
    Albrecht, Hugo
    Milne, Robert
    Wang, Shudong
    CANCER RESEARCH, 2018, 78 (13)
  • [29] Discovery of a novel and highly selective CDK9 kinase inhibitor (JS']JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models
    Wang, Li
    Hu, Chen
    Wang, Aoli
    Chen, Cheng
    Wu, Jiaxin
    Jiang, Zongru
    Zou, Fengming
    Yu, Kailin
    Wu, Hong
    Liu, Juan
    Wang, Wenliang
    Wang, Zuowei
    Wang, Beilei
    Qi, Ziping
    Liu, Qingwang
    Wang, Wenchao
    Li, Lili
    Ge, Jian
    Liu, Jing
    Liu, Qingsong
    INVESTIGATIONAL NEW DRUGS, 2020, 38 (05) : 1272 - 1281
  • [30] In vitro evaluation of apixaban, a novel, potent, selective and orally bioavailable factor Xa inhibitor.
    Luettgen, Joseph M.
    Bozarth, Tracy A.
    Bozarth, Jeffrey M.
    Barbera, Frank A.
    Lam, Patrick Y.
    Quan, Mimi L.
    Pinto, Donald J.
    Wexler, Ruth R.
    Rendina, Alan R.
    Knabb, Robert M.
    BLOOD, 2006, 108 (11) : 112B - 112B