Glycobiology: The case of the missing base (vol 8, pg 952, 2012)

被引:12
|
作者
Withers, Stephen G.
Davies, Gideon J.
机构
[1] University of British Columbia,Stephen G. Withers is at the Department of Chemistry
[2] Vancouver,Gideon J. Davies is at the Department of Chemistry
[3] British Columbia,undefined
[4] Canada.,undefined
[5] The University of York,undefined
[6] York,undefined
[7] UK.,undefined
关键词
D O I
10.1038/nchembio.1117
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Post-translational modification of proteins by N-acetylglucosamine (O-GlcNAc) is carried out by a single glycosyltransferase, OGT. Two independent groups have generated structures of ternary complexes that elegantly illuminate substrate and product binding modes, and thus the overall reaction coordinate, but the respective authors differ in their choice of catalytic base.
引用
收藏
页码:952 / 953
页数:1
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