Oncogenic fusions: Targeting NTRK

被引:5
|
作者
Hagopian, Garo [1 ]
Nagasaka, Misako [1 ,2 ,3 ]
机构
[1] Univ Calif Irvine, Med Ctr, Dept Med, Orange, CA 92868 USA
[2] St Marianna Univ, Sch Med, Dept Med, Kawasaki, Japan
[3] Univ Calif Irvine, Sch Med, 101 City Dr, Orange, CA 92868 USA
关键词
Neurotrophic tyrosine receptor kinase; Entrectinib; Larotrectinib; Repotrectinib; TRK related adverse events; POSITIVE SOLID TUMORS; ACQUIRED-RESISTANCE; TRK INHIBITOR; KINASE; LAROTRECTINIB; ENTRECTINIB; EFFICACY; NEUROTROPHIN; TROPOMYOSIN; RECEPTORS;
D O I
10.1016/j.critrevonc.2023.104234
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Non-Small Cell Lung Cancer (NSCLC) is responsible for the highest number of cancer-related deaths in the United States. Thankfully, advancements in the detection and targeting of gene mutations have greatly improved outcomes for many patients. One significant mutation driving oncogenesis in various cancers, including NSCLC, is the neurotrophic tyrosine receptor kinase (NTRK) fusion. Presently, larotrectinib and entrectinib are the only FDA-approved therapies for NTRK-mutated cancers. Despite the efficacy and tolerability exhibited by these therapies, several clinical hurdles persist for physicians, including resistance mutations and limited penetration of the central nervous system (CNS), which diminishes their effectiveness. The treatment landscape for NTRK cancers is still being explored, with numerous new tyrosine kinase inhibitors currently in development or undergoing phase 1 and 2 clinical trials. In this review, we delve into both established and novel therapies targeting NTRK-mutated NSCLC.
引用
收藏
页数:8
相关论文
共 50 条
  • [31] NTRK FUSIONS IN PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
    Dahl, Nathan
    Donson, Andrew
    Wang, Dong
    Foreman, Nicholas
    Baker, Suzanne
    Tinkle, Christopher
    Jones, Chris
    Bailey, Simon
    Vibhakar, Rajeev
    Hoffman, Lindsey
    NEURO-ONCOLOGY, 2019, 21 : 74 - 75
  • [32] Molecular and Clinicopathologic Features of Gliomas Harboring NTRK Fusions
    Torre, Matthew
    Vasudevaraja, Varshini
    Meredith, David
    Serrano, Jonathan
    DeLorenzo, Michael
    Malinowski, Seth
    Blandin, Anne-Florence
    Pages, Melanie
    Ligon, Azra
    Nasrallah, MacLean
    Horbinski, Craig
    Dahiya, Sonika
    Ligon, Keith
    Santi-Vicini, Mariarita
    Ramkissoon, Shakti
    Snuderl, Matija
    Filbin, Mariella
    Alexandescru, Sanda
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2020, 79 (06): : 657 - 657
  • [33] NTRK fusions in lung cancer: From biology to therapy
    Harada, Guilherme
    Santini, Fernando C.
    Wilhelm, Clare
    Drilon, Alexander
    LUNG CANCER, 2021, 161 : 108 - 113
  • [34] NTRK fusions in thyroid cancer: Pathology and clinical aspects
    Ma, Yanhui
    Zhang, Qi
    Zhang, Kexin
    Liang, Yunzi
    Ren, Fangbing
    Zhang, Jingwen
    Kan, Chengxia
    Han, Fang
    Sun, Xiaodong
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2023, 184
  • [35] Molecular and clinicopathologic features of gliomas harboring NTRK fusions
    Torre, Matthew
    Vasudevaraja, Varshini
    Serrano, Jonathan
    DeLorenzo, Michael
    Malinowski, Seth
    Blandin, Anne-Florence
    Pages, Melanie
    Ligon, Azra H.
    Dong, Fei
    Meredith, David M.
    Nasrallah, MacLean P.
    Horbinski, Craig
    Dahiya, Sonika
    Ligon, Keith L.
    Santi, Mariarita
    Ramkissoon, Shakti H.
    Filbin, Mariella G.
    Snuderl, Matija
    Alexandrescu, Sanda
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2020, 8 (01)
  • [36] NTRK3 kinase fusions in Spitz tumours
    Yeh, Iwei
    Tee, Meng Kian
    Botton, Thomas
    Shain, A. Hunter
    Sparatta, Alyssa J.
    Gagnon, Alexander
    Vemula, Swapna S.
    Garrido, Maria C.
    Nakamaru, Kenji
    Isoyama, Takeshi
    McCalmont, Timothy H.
    LeBoit, Philip E.
    Bastian, Boris C.
    JOURNAL OF PATHOLOGY, 2016, 240 (03): : 282 - 290
  • [37] Novel NTRK3 Fusions in Fibrosarcomas of Adults
    Yamazaki, Fumito
    Nakatani, Fumihiko
    Asano, Naofumi
    Wakai, Susumu
    Sekimizu, Masaya
    Mitani, Sachiyo
    Kubo, Takashi
    Kawai, Akira
    Ichikawa, Hitoshi
    Yoshida, Akihiko
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2019, 43 (04) : 523 - 530
  • [38] NTRK gene fusions: a rough diamond ready to sparkle
    Rolfo, Christian
    LANCET ONCOLOGY, 2020, 21 (04): : 472 - 474
  • [39] Molecular characterization of the malignancies with targetable NTRK gene fusions
    Gatalica, Zoran
    Swensen, Jeffrey
    Kimbrough, Jeffery
    Xiu, Joanne
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [40] NTRK gene fusions in bilio-pancreatic cancers
    Demols, A.
    Perez-Casanova, L.
    Rocq, L.
    Charry, M.
    De Neve, N.
    Verrellen, A.
    Ramadhan, A.
    Van Campenhout, C.
    De Clercq, S.
    Maris, C.
    Closset, J.
    Lucidi, V.
    Salmon, I.
    D'Haene, N.
    ANNALS OF ONCOLOGY, 2020, 31 : S268 - S268