The Role of EMT-Related lncRNAs in Ovarian Cancer

被引：4

作者：

Lampropoulou, Dimitra Ioanna ^{[1
]}

Papadimitriou, Marios ^{[2
,3
]}

Papadimitriou, Christos ^{[3
]}

Filippou, Dimitrios ^{[4
,5
]}

Kourlaba, Georgia ^{[6
]}

Aravantinos, Gerasimos ^{[7
]}

Gazouli, Maria ^{[8
]}

机构：

[1] ECONCARE LP, Hlth Res & Consulting, Athens 11528, Greece

[2] Univ Miami, Sylvester Comprehens Canc Ctr, Myeloma Div, Miami, FL 33136 USA

[3] Natl & Kapodistrian Univ Athens, Aretaieion Hosp, Med Sch, Dept Surg 2, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Med Sch, Dept Anat & Surg Anat, Athens 11527, Greece

[5] Natl Org Med EOF, Athens 15562, Greece

[6] Univ Peloponnese, Dept Nursing, Tripoli 22100, Greece

[7] Euroclinic, Athanasiadou 7-9, Athens 11521, Greece

[8] Natl & Kapodistrian Univ Athens, Med Sch, Dept Basic Med Sci, Lab Biol, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 12期

关键词：

lncRNAs; ovarian cancer; EMT; biomarkers; EPITHELIAL-MESENCHYMAL TRANSITION; PREDICTS POOR-PROGNOSIS; NONCODING RNA HOTTIP; COMPETING ENDOGENOUS RNA; CELL-PROLIFERATION; MOLECULAR-MECHANISMS; PRELIMINARY EFFICACY; CIRCULATING LNCRNAS; PATIENT PROGNOSIS; DNA METHYLATION;

D O I：

10.3390/ijms241210079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs' mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.

引用

页数：26

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