Time-restricted Feeding Changes as Inspiration for Drug Design

被引：0
|
作者：
He, Zhangyuting [1 ]
Yang, Huayu [2 ]
Mao, Yilei [2 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll, Beijing 100730, Peoples R China
[2] PUMC & Chinese Acad Med Sci CAMS, Peking Union Med Coll PUMC Hosp, Dept Liver Surg, Beijing 100730, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2023年 / 29卷 / 08期
关键词：
Drug design; glucose metabolism; metabolic syndrome; time-restricted feeding; melatonin; agomelatine;
D O I：
10.2174/1381612829666230307104103
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Time-restricted feeding (TRF) is a special lifestyle intervention that improves glucose metabolism, regulates lipid metabolism, increases gut micro richness, and strengthens circadian rhythm. Diabetes is a remarkable component of metabolic syndrome, and individuals with diabetes can benefit from TRF. Melatonin and agomelatine can strengthen circadian rhythm, which is a crucial mechanism of TRF. New drug designs can be inspired by the related mechanisms and influences of TRF on glucose metabolism, and more researches are needed to clarify the specific diet-related mechanisms and apply this knowledge to further drug design.
引用
收藏
页码：559 / 561
页数：3
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