Chronic Granulomatous Disease (CGD): Commonly Associated Pathogens, Diagnosis and Treatment

被引：8

作者：

Justiz-Vaillant, Angel A. ^{[1
]}

Williams-Persad, Arlene Faye-Ann ^{[1
]}

Arozarena-Fundora, Rodolfo ^{[2
,3
]}

Gopaul, Darren ^{[4
]}

Soodeen, Sachin ^{[1
]}

Asin-Milan, Odalis

Thompson, Reinand ^{[1
]}

Unakal, Chandrashekhar ^{[1
]}

Akpaka, Patrick Eberechi ^{[1
,2
]}

机构：

[1] Univ West Indies, Fac Med Sci, Dept Paraclin Sci, St Augustine, Trinidad Tobago

[2] North Cent Reg Hlth Author, Eric Williams Med Sci Complex, Champs Fleurs, Trinidad Tobago

[3] Univ West Indies, Fac Med Sci, Dept Clin & Surg Sci, St Augustine, Trinidad Tobago

[4] Univ West Indies, Port Spain Gen Hosp, Dept Internal Med, St Augustine, Trinidad Tobago

来源：

MICROORGANISMS | 2023年 / 11卷 / 09期

关键词：

chronic granulomatous disease; microorganisms; neutrophils; antimicrobials; GENE-THERAPY; CELL TRANSPLANTATION; RESPIRATORY BURST; FUNGAL-INFECTIONS; HEPATIC-ABSCESS; NADPH OXIDASE; COMPLICATIONS; INVOLVEMENT; MUTATION; FEATURES;

D O I：

10.3390/microorganisms11092233

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in the phagocytic function of the innate immune system owing to mutations in genes encoding the five subunits of the nicotinamide adenine dinucleotide phosphatase (NADPH) oxidase enzyme complex. This review aimed to provide a comprehensive approach to the pathogens associated with chronic granulomatous disease (CGD) and its management. Patients with CGD, often children, have recurrent life-threatening infections and may develop infectious or inflammatory complications. The most common microorganisms observed in the patients with CGD are Staphylococcus aureus, Aspergillus spp., Candida spp., Nocardia spp., Burkholderia spp., Serratia spp., and Salmonella spp. Antibacterial prophylaxis with trimethoprim-sulfamethoxazole, antifungal prophylaxis usually with itraconazole, and interferon gamma immunotherapy have been successfully used in reducing infection in CGD. Haematopoietic stem cell transplantation (HCT) have been successfully proven to be the treatment of choice in patients with CGD.

引用

页数：17

共 50 条

[21] CHRONIC GRANULOMATOUS DISEASE (CGD) - INVITRO ENHANCEMENT OF BACTERICIDAL ACTIVITY OF CGD PHAGOCYTES OF BY RIFAMPICIN
SAMSON, J
LAPOINTE, N
ANNALES D IMMUNOLOGIE, 1977, C128 (1-2): : 75 - 76
[22] Advances in the diagnosis and treatment of chronic granulomatous disease
Seger, Reinhard A.
CURRENT OPINION IN HEMATOLOGY, 2011, 18 (01) : 36 - 41
[23] FIBROBLAST NITROBLUE TETRAZOLIUM (NBT) TEST PRELUDE TO IN UTERO DIAGNOSIS OF CHRONIC GRANULOMATOUS (CGD) DISEASE
FIKRIG, SM
SMITHWICK, EM
SUNTHARALINGAM, K
PEDIATRIC RESEARCH, 1979, 13 (04) : 447 - 447
[24] SUCCESSFUL TREATMENT OF INVASIVE ASPERGILLUS INFECTION WITH ITRACONAZOLE IN CHRONIC GRANULOMATOUS-DISEASE (CGD)
SIMPSON, J
KENT, E
CLAASSEN, J
MILLER, D
BARRETT, M
BUCKLEY, R
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1988, 81 (01) : 286 - 286
[25] CHRONIC GRANULOMATOUS DISEASE (CGD) - INVITRO ENHANCEMENT OF BACTERICIDAL ACTIVITY OF CGD PHAGOCYTES BY RIFAMPICIN
LAPOINTE, ND
PEDIATRIC RESEARCH, 1976, 10 (04) : 400 - 400
[26] Autoimmune disease in chronic granulomatous disease (CGD): A diverse spectrum.
Ravin, Suk See Ting-De
Naumann, Nora
Friend, Julia
Ulrick, Jean
Hilligoss, Dianne
Kwateema, Nana
Malech, Harry L.
BLOOD, 2006, 108 (11) : 468A - 469A
[27] A CASE OF CHRONIC GRANULOMATOUS DISEASE (CGD) DIAGNOSED IN LATE ADULTHOOD
Gregory, N.
Zheng, T.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2024, 133 (06) : S167 - S168
[28] REPORT ON THE NATIONAL-CHRONIC-GRANULOMATOUS-DISEASE-(CGD)-REGISTRY
WINKELSTEIN, JA
BOYLE, J
BUCKLEY, RH
CURNUTTE, JT
DICKLER, H
GALLIN, JI
JOHNSTON, RB
OCHS, HD
QUIE, P
PEDIATRIC RESEARCH, 1995, 37 (04) : A11 - A11
[29] Bone Marrow Transplantation (BMT) for Chronic Granulomatous Disease (CGD)
Seger, RA
BONE MARROW TRANSPLANTATION, 2001, 27 : S34 - S34
[30] Skull Osteomyelitis as Initial Presentation of Chronic Granulomatous Disease (CGD)
Cunha, J. M.
Lucchese, N.
Burckart, K.
Soares, V.
JOURNAL OF CLINICAL IMMUNOLOGY, 2014, 34 (03) : 351 - 352

← 1 2 3 4 5 →