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- [21] Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate CancerJOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (02) : 1553 - 1571Shen, HuiXu, HongruiJin, WeiqinWu, TianbangHu, JiankangZhang, ChengZhong, ZhixinLi, JunhuaMao, RuiZhang, ShengZhang, XiaoWu, XishanSmaill, Jeff B.Xu, JinxinZhang, YanXu, Yong
- [22] BMS-986397, a First-in-Class Molecular Glue Degrader of Casein Kinase 1α (CK1α) for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS) Harboring Functional TP53BLOOD, 2024, 144 : 4142 - 4143Jimenez, CarmenPeng, SophieNarla, Rama KrishnaBaughman, JoshuaWood, ScottLu, JeanPurroy, NoeliaYanochko, GinaNagy, MarkLu, GangRolfe, MarkPierce, Daniel W.Carrancio, Soraya
- [23] MIDOSTAURIN (MIDO) DEMONSTRATES A FAVORABLE SAFETY PROFILE IN OLDER PATIENTS (PTS) WITH ACUTE MYELOID LEUKEMIA (AML) OR MYELODYSPLASTIC SYNDROME (MDS)HAEMATOLOGICA, 2013, 98 : 30 - 30Fischer, T.Kantarjian, H.Feldman, E.Ehninger, G.Larson, P.Khan, M.Virkus, J.Stone, R.
- [24] BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors.JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)Chourasia, Aparajita HoskoteMajeski, HannahPasis, AngelaErdman, PaulOke, AshwiniHecht, DavidLonergan, DavidMercurio, FrankChan, KyleThai, Dung LuongFung, Leah
- [25] Discovery of SC110237, a highly potent, selective and orally active FLT3 inhibitor for the treatment of acute myeloid leukemiaCANCER RESEARCH, 2015, 75Kong, NormanGao, DaxinYang, HepingYu, Yajun
- [26] PIN-A1, a novel Casein Kinase 1α-selective molecular glue degrader, demonstrates strong antitumor activity via activation of the p53 pathway in preclinical models of AML with a favorable safety profileEUROPEAN JOURNAL OF CANCER, 2022, 174 : S20 - S20Jung, J.Park, J.Mohanty, S.Kim, Y.Levy, D.King-Underwood, J.Deninno, M.Baek, J.Choi, W.Lee, S.Lee, D.Kang, H.Brotz, T.Terrett, N.Jo, H.Kim, Y.
- [27] IMPACT OF AN EARLY INTERVENTION IN PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML) WITH NPM1 FAVORABLE GENOTYPE PRESENTING A MOLECULAR RELAPSEHAEMATOLOGICA, 2017, 102 : 317 - 318Bataller Torralba, A.Diaz Beya, M.Garrido, A.Vives, S.Vall Llovera, F.Lopez Guerra, M.Pratcorona, M.Zamora, L.Nomdedeu, J.Colomer, D.Brunet, S.Sierra, J.Esteve, J.
- [28] Analysis of Wnt and Hedgehog Pathways Regulating Protein Kinases CK1 and CK2 in Acute Myeloid Leukemia Cells and Stem Cells: Correlation with the Expression of Wnt and Hedgehog Targets and Biological and Clinical FeaturesBLOOD, 2012, 120 (21)Brancalion, AlessandraTubi, Laura QuottiManni, SabrinaCabrelle, AnnaZaffino, FortunatoGurrieri, CarmelaSemenzato, GianpietroPiazza, Francesco
- [29] The Topoisomerase-I Inhibitor Gimatecan Exhibits Potent and Selective Activities Against B-Cell Precursor Acute Lymphoblastic Leukemia with a Favorable Cardiotoxicity ProfileBLOOD, 2023, 142Wang, HanChan, Kathy Yuen YeeLee, Po YiZhang, ChiSing, HungLeung, Wai ManKwok, MaxwellChung, Po YeeNg, Wing HeiCheung, John Tak KitLam, Wai YipLi, BenjaminLi, Chi KongPoon, EllenLeung, Kam Tong
- [30] Discovery of highly potent and novel LSD1 inhibitors for the treatment of acute myeloid leukemia: structure-based virtual screening, molecular dynamics simulation, and biological evaluationFRONTIERS IN PHARMACOLOGY, 2025, 16Hong, YeWang, YutingHao, ZiyiZhang, XingxiaSi, YejunLin, GuoqiangZhang, ShurongNiu, Miao-MiaoYang, XiaotianZhang, Yanming