Role of O-GlcNAcylation in cancer biology

被引：3
|
作者：
Li, Yuxuan [1 ,2 ]
Qu, Shuhan [1 ,2 ]
Jin, Hai [3 ]
Jia, Qingge [4 ]
Li, Mingyang [1 ,2 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Pathol, State Key Lab Canc Biol, Xian, Peoples R China
[2] Fourth Mil Med Univ, Sch Basic Med, Xian, Peoples R China
[3] Gen Hosp Northern Theater Command, Dept Neurosurg, Shenyang, Peoples R China
[4] Northwest Univ, Xian Int Med Ctr Hosp, Dept Reprod Med, Xian, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 253卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
O-GlcNAcylation; Cancer; Tumor phenotypes; NF-KAPPA-B; GLCNAC-MODIFICATION; ONCOGENIC TRANSCRIPTION; PANCREATIC-CANCER; CROSS-TALK; GLUCOSE; PHOSPHORYLATION; CELLS; ACETYLGLUCOSAMINE; INFLAMMATION;
D O I：
10.1016/j.prp.2023.155001
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
One of the general characteristics of cancer cells is the abnormal increase of O-GlcNAcylation. Recent studies have shown that it affects the basic functions of proteins and regulates multiple phenotypes of cancer cells through key signals and metabolic pathways. O-GlcNAcylation is a covalent linkage between the beta-D-N-acetyl-glucosamine (GlcNAc) sugar and target protein. It interacts with many other types of post-translational modifications and works together in the whole process of cancer development. For example, it regulates cell activities such as cell signal transduction, transcription, cell division, metabolism and cytoskeleton regulation. In this review, we summarized the general concept of O-GlcNAcylation and its related role in the ten major tumor phenotypes.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] The role of protein O-GlcNAcylation in diabetic cardiomyopathy
    Chatham, John C.
    Wende, Adam R.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2024, 52 (06) : 2343 - 2358
  • [22] The role of O-GlcNAcylation in immunity against infections
    Quik, Marjolein
    Hokke, Cornelis H.
    Everts, Bart
    IMMUNOLOGY, 2020, 161 (03) : 175 - 185
  • [23] O-GlcNAcylation regulation of cellular signaling in cancer
    Ciraku, Lorela
    Esquea, Emily M.
    Reginato, Mauricio J.
    CELLULAR SIGNALLING, 2022, 90
  • [24] O-GlcNAcylation and neurodegeneration
    Wani, Willayat Y.
    Chatham, John C.
    Darley-Usmar, Victor
    McMahon, Lori L.
    Zhang, Jianhua
    BRAIN RESEARCH BULLETIN, 2017, 133 : 80 - 87
  • [25] New Insights Into the Biology of Protein O-GlcNAcylation: Approaches and Observations
    Mueller, Toni
    Ouyang, Xiaosen
    Johnson, Michelle S.
    Qian, Wei-Jun
    Chatham, John C.
    Darley-Usmar, Victor
    Zhang, Jianhua
    FRONTIERS IN AGING, 2021, 1
  • [26] The essential role of O-GlcNAcylation in hepatic differentiation
    Robarts, Dakota R.
    Kotulkar, Manasi
    Paine-Cabrera, Diego
    Venneman, Kaitlyn K.
    Hanover, John A.
    Zachara, Natasha E.
    Slawson, Chad
    Apte, Udayan
    HEPATOLOGY COMMUNICATIONS, 2023, 7 (11) : e0283
  • [27] The role of O-GlcNAcylation in innate immunity and inflammation
    Wang, Yongqiang
    Fang, Xiuwu
    Wang, Shuai
    Wang, Bin
    Chu, Feng
    Tian, Zhixin
    Zhang, Long
    Zhou, Fangfang
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2023, 14 (09)
  • [28] Role of O-GlcNAcylation in cell signaling and pathophysiology
    Issad, Tarik
    AMINO ACIDS, 2015, 47 (08) : 1644 - 1644
  • [29] Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma
    Zhou, Xinyu
    Hang, Sirui
    Wang, Qingqing
    Xu, Liu
    Wang, Peter
    BIOMOLECULES, 2024, 14 (08)
  • [30] THE ESSENTIAL ROLE OF O-GLCNACYLATION IN THE TESTIS AGING
    Qian, Z.
    Li, C.
    Zhao, W.
    Yao, B.
    JOURNAL OF SEXUAL MEDICINE, 2023, 20
12345