Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

被引：16
|
作者：
Cheng, Xiao [1 ,2 ]
Henick, Brian S. [3 ]
Cheng, Ke [4 ]
机构：
[1] Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Chapel Hill, NC 27599 USA
[2] North Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27606 USA
[3] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
[4] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
来源：
ACS NANO | 2024年 / 18卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Extracellular vesicles; Cancer therapy; Nanomedicine; Cancer metastasis; Biomaterials; Drug delivery; Cancer Vaccine; Immunotherapy; TUMOR-ANTIGENS; MICRORNA BIOGENESIS; EXOSOME BIOGENESIS; DELIVERY; SECRETION; CELLS; INHIBITION; VACCINE; MICROVESICLE; DOXORUBICIN;
D O I：
10.1021/acsnano.3c06462
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Extracellular vesicles (EVs) are natural lipid nanoparticles secreted by most types of cells. In malignant cancer, EVs derived from cancer cells contribute to its progression and metastasis by facilitating tumor growth and invasion, interfering with anticancer immunity, and establishing premetastasis niches in distant organs. In recent years, multiple strategies targeting cancer-derived EVs have been proposed to improve cancer patient outcomes, including inhibiting EV generation, disrupting EVs during trafficking, and blocking EV uptake by recipient cells. Developments in EV engineering also show promising results in harnessing cancer-derived EVs as anticancer agents. Here, we summarize the current understanding of the origin and functions of cancer-derived EVs and review the recent progress in anticancer therapy targeting these EVs.
引用
收藏
页码：6748 / 6765
页数：18
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