Bioactive mixed-ligand zinc(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives

被引：8

作者：

Ermakova, Ekaterina A. ^{[1
]}

Golubeva, Julia A. ^{[1
]}

Smirnova, Ksenia S. ^{[1
]}

Klyushova, Lyubov S. ^{[2
]}

Eltsov, Ilia V. ^{[3
]}

Zubenko, Alexander A. ^{[4
]}

Fetisov, Leonid N. ^{[4
]}

Svyatogorova, Alexandra E. ^{[4
]}

Lider, Elizaveta V. ^{[1
]}

机构：

[1] SB RAS, Nikolaev Inst Inorgan Chem, 3 Acad Lavrentiev Ave, Novosibirsk 630090, Russia

[2] Fed State Budget Sci Inst, Fed Res Ctr Fundamental & Translat Med IMBB FRC FT, Inst Mol Biol & Biophys, 2-12 Timakova Str, Novosibirsk 630060, Russia

[3] Novosibirsk State Univ, 1 Pirogova Str, Novosibirsk 630090, Russia

[4] Branch Fed State Budget Sci Inst, North Caucasian Zonal Sci Res Vet Inst, Fed Rostov Agr Res Ctr, 0 Rostovskoye Shosse, Novocherkassk 346421, Russia

来源：

POLYHEDRON | 2023年 / 230卷

基金：

俄罗斯科学基金会;

关键词：

Zinc(II) complexes; Oligopyridine; Tetrazole; Crystal structure; Cytotoxicity; DNA-BINDING; MOLECULAR DOCKING; NUCLEASE ACTIVITY; CRYSTAL-STRUCTURE; DNA/BSA BINDING; CYTOTOXICITY; COPPER(II); CELL; 2,2'-BIPYRIDINE; 1,10-PHENANTHROLINE;

D O I：

10.1016/j.poly.2022.116213

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

1H-tetrazole-5-acetic acid is bifunctional ligand that was employed for the synthesis of zinc(II) complexes in the presence of secondary ligands such as oligopyridines (dmphen - 4,7-dimethyl-1,10-phenanthroline, phendione - 1,10-phenanthroline-5,6-dione, phen - 1,10-phenanthroline, dmbipy - 2,2'-bi-4-picoline, bipy - 2,2'-bipyridine). Five new mixed-ligand zinc(II) complexes [Zn(dmphen)L]center dot H2O (1), [Zn(phendione)(H2O)L]center dot 2H(2)O (2), [Zn(phen) L]center dot 0,5H(2)O (3), {[Zn(dmbipy)L]center dot H2O}(n) (4) and [Zn(bipy)L]center dot H2O (5) have been synthesized and characterized by elemental analysis, IR spectroscopy and powder X-ray diffraction. All complexes have shown to possess thermal stability up to 250 degrees C by thermogravimetric analysis, except for complexes 2 and 5, which have been stable up to 200 degrees C. Crystal structures of polymeric complexes {[Zn(dmphen)(H2O)(2)L]center dot 2H(2)O}(n) (1a) and 4 have been determined by single-crystal X-ray diffraction analysis. The effect of the compounds on viability of HepG-2, MCF-7 and MRC-5 cell lines has been investigated. Complex 2 was found to be the most cytotoxic with IC50 values of 6.4 +/- 0.9 mu M for HepG-2 cells and 2.6 +/- 1.1 mu M for MCF-7 cells. The antimicrobial activity of the complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii.

引用

页数：10

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