Sesquiterpenoids and monoterpenoids from the water decoction of Valeriana officinalis L

被引：7

作者：

Li, Shi-Wei ^{[1
]}

Xue, Bian-Xia ^{[1
]}

Yang, Tian-Tian ^{[1
]}

Li, Ran ^{[1
]}

Zhang, Mingjie ^{[2
]}

Wang, Miao ^{[1
]}

Zhang, Li-Hua ^{[1
]}

Zhang, Peng ^{[1
]}

Zhang, Yi ^{[1
]}

Wang, Tao ^{[1
]}

Wang, Shao-Xia ^{[2
]}

Wu, Hong-Hua ^{[1
,3
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, State Key Lab Component based Chinese Med, 10 Poyanghu Rd,West Area,Tuanbo New Town, Tianjin 301617, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, 10 Poyanghu Rd,West Area,Tuanbo New Town, Tianjin 301617, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, 10 Poyanghu Rd,West Area,Tuanbo New Town, Tianjin 301617, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 205卷

关键词：

Valeriana officinalis L; Valerianaceae; Water decoction; Sesquiterpenoids; Iridoids; Anti-neuroinflammatory activity; CHEMICAL-CONSTITUENTS; IRIDOIDS; ROOTS; EXTRACTS; RHIZOMES; LEAVES; PARTS;

D O I：

10.1016/j.phytochem.2022.113474

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine previously undescribed compounds including three sesquiterpenoids, three iridoids, two monoterpenoids and a furan fatty acid, along with seventeen known ones, were isolated from the water decoction of roots and rhizomes of Valerian officinalis L. Structure elucidation of the twenty-six compounds were accomplished by analysis of the extensive spectroscopic data, and the absolute configurations of the nine previously undescribed ones were established by NOESY experiment and the electronic circular dichroism (ECD) simulations. Among them, beta-patchoulene-8-O-beta-D-glucopyranoside, 11-methoxyl-viburtinal, and protocatechuic acid showed anti-neuroinflammatory potentials by significantly inhibiting the secretion of nitric oxide (NO) on BV-2 cells upon LPS stimulation (p < 0.001) without affecting the cell viability.

引用

页数：11

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