With its long coastline, vast exclusive economic zone (EEZ), skilled labor force, advanced technology, and one of the largest seafood markets in the world, the United States could be a major marine aquaculture producer of fish, mollusks, crustaceans, and marine algae. Despite all its promise, U.S. marine aquaculture production is tiny relative to its potential. The constraints often cited are lack of social license, an inefficient and uncoordinated permitting system, and the absence of supportive government programs similar to those enjoyed by terrestrial agriculture. National commissions have noted these constraints for more than 30 years. The paper first outlines key policy drivers prompting a reevaluation of US marine aquaculture policy (human health and nutrition, climate change, and market disruptions caused by the coronavirus) and then focuses on three critical policy goals that could contribute to expanding U.S. seafood farming: improve public understanding and acceptance, enhance the efficiency and timeliness of the aquaculture permitting process, and expand economic incentives to foster aquaculture development.