Advances in Understanding and Treating Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review

被引:3
|
作者
Gupta, Deepal [1 ]
Vagha, Sunita [2 ]
Dhingra, Hitaansh [1 ]
Shirsath, Hrishita [1 ]
机构
[1] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Med, Wardha, India
[2] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Pathol, Wardha, India
关键词
physical medicine and rehabilitation; stem cell therapy; neurodegenerative disesase; masitinib; human genetics and epigenetics; familial amyotrophic lateral sclerosis; ANTISENSE OLIGONUCLEOTIDE; MANAGEMENT; CHANNELS; PROGRESS; THERAPY;
D O I
10.7759/cureus.48691
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Amyotrophic lateral sclerosis (ALS) is a deadly CNS neurodegenerative disease. The way ALS is now managed, from diagnosis to prognosis, is still not ideal despite many studies. Early diagnosis can help ALS patients live longer since prompt treatment can halt the disease's development. Two medications, riluzole and edaravone, have recently been licensed for use in therapy, and they very slightly increase life expectancy. Still, a lot of cutting-edge experimental medications are being developed. In the following article, we give a synopsis of the innovative medications and genetic remodeling that have emerged recently and help to halt the course of the illness. Studies have also been conducted on a few symptomatic and rehabilitative therapies that enhance the quality of life for ALS patients.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Correlates of suffering in amyotrophic lateral sclerosis (ALS)
    Ganzini, L
    Johnston, W
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1998, 46 (09) : S10 - S10
  • [42] Motoneuron firing in amyotrophic lateral sclerosis (ALS)
    de Carvalho, Mamede
    Eisen, Andrew
    Krieger, Charles
    Swash, Michael
    FRONTIERS IN HUMAN NEUROSCIENCE, 2014, 8
  • [43] AN IMMUNOLOGICAL PROFILE OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    MALIN, JP
    NERVENARZT, 1990, 61 (02): : 105 - 111
  • [44] Diagnosing amyotrophic lateral sclerosis (ALS) in ENT
    Harrison, L.
    Wills, A.
    Beasley, N.
    CLINICAL OTOLARYNGOLOGY, 2013, 38 (06) : 564 - 565
  • [45] Lead exposure and amyotrophic lateral sclerosis (ALS).
    Kamel, F
    Umbach, DM
    Hu, H
    Munsat, TL
    Shefner, JM
    Sandler, DP
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (11) : S75 - S75
  • [46] Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors
    Sebastiao, Ana M.
    Rei, Nadia
    Ribeiro, Joaquim A.
    FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [47] Drug repurposing in amyotrophic lateral sclerosis (ALS)
    Carroll, Emily
    Scaber, Jakub
    Huber, Kilian V. M.
    Brennan, Paul E.
    Thompson, Alexander G.
    Turner, Martin R.
    Talbot, Kevin
    EXPERT OPINION ON DRUG DISCOVERY, 2025,
  • [48] LINKAGE IN FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    SIDDIQUE, T
    PERICAKVANCE, MA
    BROOKS, BR
    BIAS, W
    WALKER, N
    SIDDIQUE, N
    HUNG, WY
    ROSES, AD
    CYTOGENETICS AND CELL GENETICS, 1987, 46 (1-4): : 692 - 692
  • [49] Diagnostic biomarkers for amyotrophic lateral sclerosis (ALS)
    Bowser, R
    Ranganathan, S
    Ganchev, P
    Gopalakrishnan, V
    Cudkowicz, M
    Brown, RH
    FASEB JOURNAL, 2005, 19 (05): : A1511 - A1511
  • [50] Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS)
    Grad, Leslie I.
    Rouleau, Guy A.
    Ravits, John
    Cashman, Neil R.
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2017, 7 (08):