Mosunetuzumab Plus Polatuzumab Vedotin Demonstrates a Favorable Safety Profile and Efficacy in Patients (Pts) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma ( LBCL): Primary Analysis of a Phase Ib/II Study

被引:7
|
作者
Budde, L. Elizabeth [1 ]
Olszewski, Adam J. [2 ]
Assouline, Sarit [3 ]
Lossos, Izidore S. [4 ]
Diefenbach, Catherine [5 ]
Kamdar, Manali [6 ]
Ghosh, Nilanjan [7 ]
Modi, Dipenkumar [8 ]
Sabry, Waleed [9 ]
Naik, Seema [10 ]
Mehta, Amitkumar [11 ]
Nakhoda, Shazia K. [12 ]
Smith, Stephen D. [13 ]
Dorritie, Kathleen [14 ]
Jia, Ting [15 ]
Pham, Song [16 ]
Huw, Ling-Yuh [17 ]
Wu, Hao [17 ]
To, Iris [17 ]
Wei, Michael C. [17 ]
Chavez, Julio C. [18 ]
机构
[1] City Hope Natl Med Ctr, Duarte, CA USA
[2] Brown Univ, Lifespan Canc Inst, Legorreta Canc Ctr, Providence, RI USA
[3] McGill Univ, Jewish Gen Hosp, Montreal, PQ, Canada
[4] Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA
[5] NYU Langone Hlth, Perlmutter Canc Ctr, New York, NY USA
[6] Univ Colorado, Aurora, CO USA
[7] Atrium Hlth, Levine Canc Inst, Charlotte, NC USA
[8] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Detroit, MI USA
[9] Univ Saskatchewan, Saskatoon Canc Ctr, Coll Med, Saskatoon, SK, Canada
[10] Penn State Canc Inst, Hershey, PA USA
[11] Univ Alabama Birmingham, Birmingham, AL USA
[12] Fox Chase Canc Ctr, Philadelphia, PA USA
[13] Univ Washington, Fred Hutchinson Canc Ctr, Seattle, WA USA
[14] Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA USA
[15] Roche China Holding Ltd, Shanghai, Peoples R China
[16] F Hoffmann Roche Ltd, Basel, Switzerland
[17] Genentech Inc, San Francisco, CA USA
[18] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
关键词
D O I
10.1182/blood-2023-174209
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:6
相关论文
共 50 条
  • [31] Safety and efficacy of polatuzumab vedotin plus obinutuzumab for relapsed/refractory non-Hodgkin lymphomas: A phase IB/II study
    Phillips, Tycel
    Brunvand, Mark
    Chen, Andy I.
    Essell, James
    Chiappella, Annalisa
    Diefenbach, Catherine
    Cheng, Ji
    Ramies, David
    Hirata, Jamie
    Morschhauser, Franck
    Flinn, Ian W.
    AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (01) : E24 - E27
  • [32] Polatuzumab vedotin plus bendamustine and rituximab in relapsed/refractory diffuse large B-cell lymphoma: A phase III bridging study in Chinese patients
    Song, Yuqin
    Zhang, Qingyuan
    Cai, Qingqing
    Song, Yongping
    Zhang, Liling
    He, Pengcheng
    Wang, Li
    Hirata, Jamie
    Musick, Lisa
    Deng, Rong
    Liu, Wenxin
    Wang, Xin
    Zhu, Jun
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2024, 20 (07)
  • [33] Mosunetuzumab and Polatuzumab Vedotin Demonstrates Preliminary Efficacy in Elderly Unfit/Frail Patients with Previously Untreated Diffuse Large B-Cell Lymphoma
    Olszewski, Adam J.
    Eradat, Herbert
    Avigdor, Abraham
    Horowitz, Netanel A.
    Babu, Sunil
    Levi, Itai
    McKinney, Matthew
    Lee, Seung Tae
    Bergua Burgues, Juan Miguel
    Rodriguez Izquierdo, Antonia
    Bastos-Oreiro, Mariana
    Ganzel, Chezi
    Kim, Tae Min
    Jeon, Youngwoo
    Taszner, Michal
    Narkhede, Mayur
    Kim, Won Seog
    Shin, Ho-Jin
    Lavie, David
    Woszczyk, Dariusz
    Dunshee, Diana
    Kapp, Amy V.
    Zhou, Mingzhu
    Batlevi, Connie Lee
    Ead, Wahib
    Sellam, Gila
    Jurczak, Wojciech
    BLOOD, 2023, 142
  • [34] Efficacy and safety of polatuzumab-vedotin plus bendamustine and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma: A systematic review and meta-analysis☆
    Farooqi, Hanzala Ahmed
    Ullah, Muhammad Saffi
    Raza, Ahmed
    Sadiq, Zain
    Shaikh, Wardah Ali
    Muhammad, Rahmah
    Hussain, Muhammad Shoaib
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2025, 207
  • [35] Polatuzumab vedotin plus bendamustine and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma in the real world
    Vodicka, Prokop
    Benesova, Katerina
    Janikova, Andrea
    Prochazka, Vit
    Belada, David
    Mocikova, Heidi
    Steinerova, Katerina
    Duras, Juraj
    Karban, Josef
    Hanackova, Veronika
    Sykorova, Alice
    Obr, Ales
    Trneny, Marek
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2022, 109 (02) : 162 - 165
  • [36] Polatuzumab vedotin plus obinutuzumab plus venetoclax in patients with relapsed/refractory (R/R) follicular lymphoma (FL): Primary analysis of a phase 1b/2 trial.
    Bannerji, Rajat
    Yuen, Sam
    Phillips, Tycel Jovelle
    Arthur, Christopher
    Isufi, Iris
    Marlton, Paula
    Seymour, John Francis
    Corradini, Paolo
    Molinari, Annalia
    Gritti, Giuseppe
    Emmons, Robert
    Hirata, Jamie
    Musick, Lisa
    Saha, Sourish
    Croft, Brandon
    Flowers, Christopher
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [37] Exposure-safety and exposure-efficacy analyses of polatuzumab vedotin in patients with relapsed or refractory diffuse large B-cell lymphoma
    Lu, Tong
    Gibiansky, Leonid
    Li, Xiaobin
    Li, Chunze
    Shi, Rong
    Agarwal, Priya
    Hirata, Jamie
    Miles, Dale
    Chanu, Pascal
    Girish, Sandhya
    Jin, Jin Yan
    Lu, Dan
    LEUKEMIA & LYMPHOMA, 2020, 61 (12) : 2905 - 2914
  • [38] Glofitamab monotherapy in pts with relapsed/refractory (R/R) large B-cell lymphoma (LBCL): Extended follow-up and landmark analyses from a pivotal phase II study
    Falchi, Lorenzo
    Carlo-Stella, Carmelo
    Morschhauser, Franck
    Hutchings, Martin
    Bachy, Emmanuel
    Cartron, Guillaume
    Khan, Cyrus
    Tani, Monica
    Martinez-Lopez, Joaquin
    Bartlett, Nancy L.
    Salar, Antonio
    Brody, Joshua
    Leppa, Sirpa
    Mulvihill, Estafania
    Lundberg, Linda
    Relf, James
    Xie, Yuying
    Bottos, Alessia
    Humphrey, Kathryn
    Dickinson, Michael
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [39] A Phase 2 Study of Loncastuximab Tesirine Plus Mosunetuzumab in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma
    Kambhampati, Swetha
    Kallam, Avyakta
    Borogovac, Azra
    Chen, Lu
    Puverel, Sandrine
    Johnson, Jennifer
    Melgar, Ivana
    Baird, John H.
    Danilov, Alexey
    Godfrey, James
    Khan, Niloufer
    Mei, Matthew
    Phillips, Tycel J. J.
    Siddiqi, Tanya
    Shouse, Geoffrey
    Zain, Jasmine
    Kwak, Larry W.
    Rosen, Steven T.
    Forman, Stephen J.
    Song, Joo Y.
    Herrera, Alex F.
    Budde, Elizabeth
    BLOOD, 2024, 144 : 17421 - 17422
  • [40] Polatuzumab vedotin to treat relapsed or refractory diffuse large B-cell lymphoma, in combination with bendamustine plus rituximab
    Amaya, M. L.
    Jimeno, A.
    Kamdar, M.
    DRUGS OF TODAY, 2020, 56 (04) : 287 - 294