Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children

被引:3
|
作者
Arslan, Gazi [1 ]
Besci, Tolga [1 ]
Ozdemir, Goktug [1 ]
Evren, Gultac [1 ]
Tuzen, Hande Ilgaz [1 ]
Prencuva, Pinar [1 ]
Turan, Bengisu [1 ]
Benligul, Ebru Melek [1 ]
机构
[1] Dokuz Eylul Univ, Fac Med, Dept Pediat, Div Pediat Intens Care, TR-35220 Konak, Turkiye
来源
CHILDREN-BASEL | 2023年 / 10卷 / 11期
关键词
mortality; pediatric critical care; albumin; lactate; sepsis; C-REACTIVE PROTEIN; PEDIATRIC INTENSIVE-CARE; IN-HOSPITAL MORTALITY; SERUM LACTATE; PROTEIN/ALBUMIN RATIO; INDEPENDENT PREDICTOR; SEPSIS; BIOMARKERS; DISCHARGE; SYSTEM;
D O I
10.3390/children10111731
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The accurate prediction of the prognosis for critically ill children is crucial, with the Pediatric Index of Mortality (PIM) and Pediatric Risk of Mortality (PRISM) being extensively utilized for this purpose. Albumin, C-reactive protein (CRP), and lactate levels, which are indicative of inflammation and circulatory status in critically ill children, have not been incorporated into existing scoring systems. This retrospective cohort study evaluated the association between biological markers and the clinical outcomes in children with critical illnesses. PRISM-4 and PIM-3 death probability (DP), albumin, lactate, CRP, and CRP/albumin ratio were recorded upon admission. The accuracy of the indexes in predicting mortality were assessed by calculating the area under the curve (AUC). There were 942 patients included and the 28-day mortality rate was 7.9%. The AUC for PRISM-4, PIM-3, CRP, CRP/albumin ratio, albumin, and lactate were 0.923, 0.896, 0.798, 0.795, 0.751, 0.728, respectively. The findings in the subgroup analysis of septic patients were similar to those found in the overall population. Although CRP, CRP/albumin ratio, albumin, and lactate levels are all linked to mortality in children, CRP and the CRP/albumin ratio have lower predictive values than albumin and lactate. Incorporation of albumin and lactate into scoring systems will improve predictability.
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页数:10
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